Evidence map›Paper›PMID 39117985›Full record

ArticleCell biochemistry and biophysics2024

Effects of Aging on Intrinsic Protein Disorder in Human Lenses and Zonules.

Michael Antonietti, Colin K Kim, Mak B Djulbegovic, David J Taylor Gonzalez, Jason A Greenfield, Vladimir N Uversky, Allister G Gibbons, Carol L Karp

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In one paragraph

Article in Cell biochemistry and biophysics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael AntoniettiBascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
Colin K KimBascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
Mak B DjulbegovicWills Eye Hospital, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
David J Taylor GonzalezBascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
Jason A GreenfieldBascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
Vladimir N UverskyDepartment of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Allister G GibbonsBascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
Carol L KarpBascom Palmer Eye Institute, University of Miami, Miami, FL, USA. ckarp@med.miami.edu.

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
NEI NIH HHS P30 EY014801NIH Center Core Grant P30EY014801
6 · The paper itself

Abstract

This study aims to compare the levels of intrinsic protein disorder within the human lens and zonule proteomes and investigate the role of aging as a potential influencing factor on disorder levels. A cross-sectional proteomic analysis was employed, utilizing a dataset of 1466 proteins derived from the lens and zonule proteomes previously published by Wang et al. and De Maria et al. Bioinformatics tools, including a composition profiler and a rapid intrinsic disorder analysis online tool, were used to conduct a comparative analysis of protein disorder. Statistical tests such as ANOVA, Tukey's HSD, and chi-squared tests were applied to evaluate differences between groups. The study revealed distinct amino acid compositions for each proteome, showing a direct correlation between aging and increased protein disorder in the zonular proteomes, whereas the lens proteomes exhibited the opposite trend. Findings suggest that age-related changes in intrinsic protein disorder within the lens and zonule proteomes may be linked to structural transformations in these tissues. Understanding how protein disorder evolves with age could enhance knowledge of the molecular basis for age-related conditions such as cataracts and pseudoexfoliation, potentially leading to better therapeutic strategies.

Indexed as

AgingLens, CrystallineAdultAgedAmino AcidsCross-Sectional StudiesEye ProteinsHumansIntrinsically Disordered ProteinsMiddle AgedProteomeProteomicsAmino AcidsEye ProteinsIntrinsically Disordered ProteinsProteomebioinformaticsIntrinsically disordered proteinsLensproteomicsZonules

Identifiers

PMID39117985
PMCPMC11576620

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.