Evidence map›Paper›PMID 39117982›Full record

ArticleNature aging2024

Age-associated clonal B cells drive B cell lymphoma in mice.

José P Castro, Anastasia V Shindyapina, Alessandro Barbieri, Kejun Ying, Olga S Strelkova, João A Paulo, Alexander Tyshkovskiy, Rico Meinl, Csaba Kerepesi, Anna P Petrashen and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

José P Castro *Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2627-5331
Anastasia V Shindyapina *Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Alessandro BarbieriBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kejun YingBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1791-6176
Olga S StrelkovaEaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
João A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4291-413X
Alexander TyshkovskiyBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6215-190X
Rico MeinlRetro Biosciences, Redwood City, CA, USA.
Csaba KerepesiBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9541-246X
Anna P PetrashenDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Marco MariottiBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7411-4161
Margarita V MeerBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Yan HuBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Alexander KaramyshevCollege of Natural Sciences, The University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0001-5026-247X
Grigoriy LosyevBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mafalda Galhardoi3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Elsa Logarinhoi3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Artur A IndzhykulianEaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2076-6818
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7626-0034
John M SedivyDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.ORCID http://orcid.org/0000-0001-9363-4253
John P ManisBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3630-778X
Vadim N GladyshevBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. vgladyshev@rics.bwh.harvard.edu.ORCID http://orcid.org/0000-0002-0372-7016

Funding

Molecular Basis of Hair Cell Stereocilia Bundle MorphologyR01DC017166 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI INDZHYKULIAN, ARTUR · 2018 to 2022
$3.5M
Unbiased identification of interventions that extend lifespanR01AG067782 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 2019 to 2023
$3.5M
Development of Gene Therapy for Hereditary Deafness using Rational Protein EngineeringR01DC020190 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI DAVID P COREY, Artur Indzhykulian · 2022 to 2026
$3.3M
NIDCD NIH HHS R01 DC017166U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG067782
6 · The paper itself

Abstract

Although cancer is an age-related disease, how the processes of aging contribute to cancer progression is not well understood. In this study, we uncovered how mouse B cell lymphoma develops as a consequence of a naturally aged system. We show here that this malignancy is associated with an age-associated clonal B cell (ACBC) population that likely originates from age-associated B cells. Driven by c-Myc activation, promoter hypermethylation and somatic mutations, IgM

Indexed as

AgingB-LymphocytesLymphoma, B-CellAnimalsClone CellsDNA MethylationEpigenesis, GeneticHumansMiceMutationProto-Oncogene Proteins c-mycTOR Serine-Threonine KinasesProto-Oncogene Proteins c-mycTOR Serine-Threonine Kinases

Identifiers

PMID39117982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.