Evidence map›Paper›PMID 39117851›Full record

ArticleInternational journal of obesity (2005)2024

Hepatocyte-specific loss of melanocortin 1 receptor disturbs fatty acid metabolism and promotes adipocyte hypertrophy.

Keshav Thapa, Bishwa Ghimire, Kisun Pokharel, Minying Cai, Eriika Savontaus, Petteri Rinne

Abstract read
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In one paragraph

Article in International journal of obesity (2005), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Keshav ThapaResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.ORCID 0000-0002-1326-4633
Bishwa GhimireInstitute for Molecular Medicine Finland (FIMM), HiLIFE Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-5076-8366
Kisun PokharelNatural Resources Institute Finland (Luke), Jokioinen, Finland.ORCID 0000-0002-4924-946X
Minying CaiDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, USA.
Eriika SavontausResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.
Petteri RinneResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland. pperin@utu.fi.ORCID 0000-0001-6916-8627

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesMelanocortins mediate their biological functions via five different melanocortin receptors (MC1R - MC5R). MC1R is expressed in the skin and leukocytes, where it regulates skin pigmentation and inflammatory responses. MC1R is also present in the liver and white adipose tissue, but its functional role in these tissues is unclear. This study aimed at determining the regulatory role of MC1R in fatty acid metabolism.

methodsMale recessive yellow (Mc1r

resultsChow- and Western diet-fed Mc1r

conclusionsHepatocyte-specific loss of MC1R disturbs fatty acid metabolism in the liver and leads to an obesity phenotype characterized by enhanced adipocyte hypertrophy and TG accumulation in the liver and circulation.

Indexed as

AdipocytesFatty AcidsHepatocytesReceptor, Melanocortin, Type 1AnimalsHumansHypertrophyLipid MetabolismLiverMaleMiceMice, KnockoutObesityFatty AcidsMc1r protein, mouseReceptor, Melanocortin, Type 1

Identifiers

PMID39117851
PMCPMC11502480

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.