Evidence map›Paper›PMID 39117798›Full record

ArticleLeukemia2024

GNAS knockout potentiates HDAC3 inhibition through viral mimicry-related interferon responses in lymphoma.

Michael Y He, Kit I Tong, Ting Liu, Ryder Whittaker Hawkins, Victoria Shelton, Yong Zeng, Mehran Bakhtiari, Yufeng Xiao, Guangrong Zheng, Ali Sakhdari and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Michael Y HePrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-2235-2758
Kit I TongPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Ting LiuPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-8775-5507
Ryder Whittaker HawkinsDepartment of Immunology, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-4018-5236
Victoria SheltonPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Yong ZengPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Mehran BakhtiariPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Yufeng XiaoDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Guangrong ZhengDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-8106-6663
Ali SakhdariLaboratory Medicine and Pathobiology, University Health Network, Toronto, ON, Canada.
Lin YangPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Wenxi XuPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
David G BrooksPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Rob C LaisterPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Housheng Hansen HePrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Robert KridelPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. robert.kridel@uhn.ca.ORCID 0000-0003-0287-7124

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite selective HDAC3 inhibition showing promise in a subset of lymphomas with CREBBP mutations, wild-type tumors generally exhibit resistance. Here, using unbiased genome-wide CRISPR screening, we identify GNAS knockout (KO) as a sensitizer of resistant lymphoma cells to HDAC3 inhibition. Mechanistically, GNAS KO-induced sensitization is independent of the canonical G-protein activities but unexpectedly mediated by viral mimicry-related interferon (IFN) responses, characterized by TBK1 and IRF3 activation, double-stranded RNA formation, and transposable element (TE) expression. GNAS KO additionally synergizes with HDAC3 inhibition to enhance CD8

Indexed as

ChromograninsGTP-Binding Protein alpha Subunits, GsHistone DeacetylasesLymphomaAnimalsCell Line, TumorGene Knockout TechniquesHistone Deacetylase 3Histone Deacetylase InhibitorsHumansInterferonsMiceSignal TransductionChromograninsGNAS protein, humanGTP-Binding Protein alpha Subunits, GsHistone Deacetylase 3Histone Deacetylase InhibitorsHistone DeacetylasesInterferons

Identifiers

PMID39117798
PMCPMC11436380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.