SynthesisScientific reports2024
Comparison of bioactive material failure rates in vital pulp treatment of permanent matured teeth - a systematic review and network meta-analysis.
Synthesis in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Management strategies for pulpitis in vital permanent teeth in children and adolescents: a systematic review and meta-analysis of randomized clinical trials.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Pooled it
- Clinical outcomes of selective removal to soft dentin versus firm dentin for deep caries lesions: a randomized controlled trial up to 5 years.Clinical oral investigations · 2024Trial
- In Vitro Comparison of Void Formation Between Calcium Silicate-Based Sealers and AH Plus: A Systematic Review and Meta-Analysis.Dentistry journal · 2026Review
- Postoperative Pain and Matrix Metalloproteinase-9 Pulpal Blood Level in Symptomatic Pulpitis of Mature Molars Treated with Biodentine and Portland Cement Full Pulpotomy: A Randomized Clinical Trial.Journal of clinical and experimental dentistry · 2026Review
- Melatonin and the Dental Pulp: A Scoping Review.International endodontic journal · 2026Article
- Indirect Pulp Treatment for Deep Carious Lesions in Mature Permanent Teeth: A Preventive, Minimally Invasive Clinical Approach.Dentistry journal · 2026Article
- Comparative success of platelet-rich fibrin and mineral trioxide aggregate in direct pulp capping and pulpotomy: a systematic review and meta-analysis.Biomaterial investigations in dentistry · 2026Review
- Vital pulp therapy using Biodentine XP and adhesive restorations: a three-year case series.Frontiers in dental medicine · 2026Article
- Decision-ready evidence for vital pulp therapy: a network meta-analysis of bioactive materials in mature permanent teeth.Frontiers in dental medicine · 2026Review
- Histologic evaluation of the effect of St John's wort (Hypericum perforatum L.) and mineral trioxide aggregate (MTA) in partial pulpotomy treatment applied to molar teeth of rats.BMC complementary medicine and therapies · 2025Article
- Epidemiology of Endodontic Treatment in Far North Queensland, Australia: A Retrospective Observational Study of 11 Years.Clinical and experimental dental research · 2025Observational
- The Washout Resistance of Bioactive Root-End Filling Materials-A Systematic Review.Journal of clinical medicine · 2025Review
- Bioceramics in Endodontics: Limitations and Future Innovations-A Review.Dentistry journal · 2025Review
- Assessment of Endocyn on Dental Pulp Stem Cells (DPSCs): A Pilot Study of Endodontic Irrigant Effects.Methods and protocols · 2025Article
- Knowledge and Attitude Toward Vital Pulp Therapy Among Dental Practitioners in Jordan: A Questionnaire-Based Survey.International journal of dentistry · 2025Article
- Histopathological Assessment of Tricalcium Aluminate-free Mineral Trioxide Aggregate and Two Antibacterial Enhanced Mineral Trioxide Aggregates As Pulpotomy Agents in Rat Model.European endodontic journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mineral Trioxide Aggregate (MTA) is the gold standard for vital pulp treatment (VPT), but its superiority over novel calcium silicate-based cements in permanent teeth lacks systematic evidence. This study aimed to compare the efficacy of these materials in VPT through a network meta-analysis. A systematic search was conducted in MEDLINE, EMBASE, Cochrane Library, and Web of Science until January 20, 2024. The inclusion criteria were randomized controlled trials involving VPT with biomaterials and reversible or irreversible pulpitis diagnoses in mature permanent teeth. The primary outcome was the odds ratio (OR) of failure rates with 95% confidence intervals. In the 21 eligible trials, failure rates were significantly higher with calcium-hydroxide than MTA at six (OR 2.26 [1.52-3.36]), 12 (OR 2.53 [1.76-3.62]), and 24 months (OR 2.46 [1.60-3.79]). Failure rates for Totalfill at six (OR 1.19 [0.55-2.58]) and 12 months (OR 1.43 [0.71-2.92]), and Biodentine at six (OR 1.09 [0.66-1.78]), 12 (OR 1.21 [0.74-1.96]), and 24 months (OR 1.47 [0.81-2.68]) were not significantly different from MTA. The results were similar in the direct pulp capping subgroup, whereas, in the partial and full pulpotomy subgroup, there was not enough evidence to achieve significant differences. MTA, Biodentine, and Totalfill are the most efficient materials for VPT. However, calcium-hydroxide-based materials are not recommended in VPT.
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Registered trials
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