Evidence map›Paper›PMID 39117701›Full record

ArticleScientific data2024

Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers.

Jessica M Logan, Carmela Martini, Alexandra Sorvina, Ian R D Johnson, Robert D Brooks, Maria C Caruso, Chelsea Huzzell, Courtney R Moore, Litsa Karageorgos, Lisa M Butler and 10 more

Abstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jessica M Logan *Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia. jessica.logan@unisa.edu.au.
Carmela Martini *Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia.
Alexandra Sorvina *Centre for Cancer Biology, University of South Australia, North Terrace, Adelaide, SA, 5000, Australia.
Ian R D JohnsonClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia.ORCID 0000-0001-7875-3510
Robert D BrooksClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia.
Maria C CarusoClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia.
Chelsea HuzzellClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia.
Courtney R MooreClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia.
Litsa KarageorgosClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia.
Lisa M ButlerSouth Australian ImmunoGENomics Cancer Institute and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA, 5005, Australia.ORCID 0000-0003-2698-3220
Prerna TewariDepartment of Histopathology, Trinity College Dublin, D02 PN40, Dublin, Ireland.
Sarita PrabhakaranDepartment of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.ORCID 0000-0003-3252-2519
Shane M HickeyClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia.
Sonja KlebeDepartment of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.
Hemamali SamaratungaAquesta Uropathology, The University of Queensland, Brisbane, QLD, 4072, Australia.
Brett DelahuntMalaghan Institute of Medical Research, Wellington, 6012, New Zealand.
Kim MorettiDiscipline of Surgery, University of Adelaide, Adelaide, SA, 5371, Australia.
John J O'LearyDepartment of Histopathology, Trinity College Dublin, D02 PN40, Dublin, Ireland.ORCID 0000-0001-7311-9326
Douglas A BrooksClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia.
Ben S-Y UngClinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia.ORCID 0000-0001-7667-3648

Funding

Department of Health | National Health and Medical Research Council (NHMRC) GNT1092904
6 · The paper itself

Abstract

The diagnosis of prostate cancer using histopathology is reliant on the accurate interpretation of prostate tissue sections. Current standards rely on the assessment of Haematoxylin and Eosin (H&E) staining, which can be difficult to interpret and introduce inter-observer variability. Here, we present a digital pathology atlas and online resource of prostate cancer tissue micrographs for both H&E and the reinterpretation of samples using a novel set of three biomarkers as an interactive tool, where clinicians and scientists can explore high resolution histopathology from various case studies. The digital pathology prostate cancer atlas when used in conjunction with the biomarkers, will assist pathologists to accurately grade prostate cancer tissue samples.

Indexed as

Adaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportBiomarkers, TumorProstatic NeoplasmsSyndecan-1HumansMaleSortilinAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportBiomarkers, TumorSortilinSyndecan-1

Identifiers

PMID39117701
PMCPMC11310308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.