ArticleNature communications2024
An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Recent Advances in Biomimetic Hydrogels for Bioelectronics and Human-Machine Interactions.Gels (Basel, Switzerland) · 2026Review
- Unifying energy and information harvesting for high-rate self-powered sensing.Science advances · 2026Article
- Robust Stitching Interface and Deep Learning Empowered Hydrogel Human-Machine Interface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Advances and Challenges in Wearable Sensors for Health Monitoring.ACS applied materials & interfaces · 2026Review
- Liquid Metals for Reconfigurable Bioelectronics.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Flexible biodegradable wireless battery-free integrated theranostic adhesive patch.Bioactive materials · 2026Article
- Tissue-adhesive hydrogel optical fiber for peripheral optogenetic neuromodulation.Nature communications · 2026Article
- An injectable, leadless bioelectronic interface for battery-free wireless peripheral neuromodulation.Science advances · 2026Article
- Hydrogel-integrated multimodal physiological and modulation systems.Materials horizons · 2026Review
- Bioresorbable acoustic patch for simultaneous sealing and early detection of gastric leakage.Science advances · 2026Article
- Wireless electrostimulation implants enable sphincter neuromuscular improvement toward mixed urinary incontinence.Nature communications · 2026Article
- AI-Enhanced Vibrational Capsule for Minimally Invasive Detection of Abnormal Bowel Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Machine learning-driven design of engineered cilia enables hybrid operations in acoustic microrobots.Nature communications · 2026Article
- Physical Intelligence in Small-Scale Robots and Machines.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Uniform and Complete Irreversible Electroporation on Gastric Mucosa Enabled by Sintered Silver Hydrogel.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- 4D printing of trigger-free shape-memory hydrogels towards self-adaptive substrates for bioelectronics.Nature communications · 2025Article
- Emerging Implantable Sensor Technologies at the Intersection of Engineering and Brain Science.Biosensors · 2025Review
- A gastric retentive robotic capsule enables emergency-prepared and responsive oral drug delivery in canine models.Science advances · 2025Article
- NFC/RFID-enabled wearables and implants for biomedical applications.Microsystems & nanoengineering · 2025Review
- A Wearable EMG-Driven Closed-Loop TENS Platform for Real-Time, Personalized Pain Modulation.Sensors (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ingestible electronics have the capacity to transform our ability to effectively diagnose and potentially treat a broad set of conditions. Current applications could be significantly enhanced by addressing poor electrode-tissue contact, lack of navigation, short dwell time, and limited battery life. Here we report the development of an ingestible, battery-free, and tissue-adhering robotic interface (IngRI) for non-invasive and chronic electrostimulation of the gut, which addresses challenges associated with contact, navigation, retention, and powering (C-N-R-P) faced by existing ingestibles. We show that near-field inductive coupling operating near 13.56 MHz was sufficient to power and modulate the IngRI to deliver therapeutically relevant electrostimulation, which can be further enhanced by a bio-inspired, hydrogel-enabled adhesive interface. In swine models, we demonstrated the electrical interaction of IngRI with the gastric mucosa by recording conductive signaling from the subcutaneous space. We further observed changes in plasma ghrelin levels, the "hunger hormone," while IngRI was activated in vivo, demonstrating its clinical potential in regulating appetite and treating other endocrine conditions. The results of this study suggest that concepts inspired by soft and wireless skin-interfacing electronic devices can be applied to ingestible electronics with potential clinical applications for evaluating and treating gastrointestinal conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.