Evidence map›Paper›PMID 39117641›Full record

ArticleNature communications2024

Printed polymer platform empowering machine-assisted chemical synthesis in stacked droplets.

Yingxue Sun, Yuanyi Zhao, Xinjian Xie, Hongjiao Li, Wenqian Feng

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yingxue SunCollege of Polymer Science and Engineering, Sichuan University, Chengdu, China.
Yuanyi ZhaoCollege of Polymer Science and Engineering, Sichuan University, Chengdu, China.
Xinjian XieCollege of Polymer Science and Engineering, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0001-8824-420X
Hongjiao LiCollege of Chemical Engineering, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0002-0388-6818
Wenqian FengCollege of Polymer Science and Engineering, Sichuan University, Chengdu, China. feng.wenqian@scu.edu.cn.ORCID http://orcid.org/0000-0003-3561-5593

Funding

National Natural Science Foundation of China (National Science Foundation of China) No. 52373214Sichuan Provincial Department of Science and Technology | Sichuan Province Science and Technology Support Program No. 2022ZYD0030State Key Laboratory of Polymer Materials Engineering No. Sklpme-2023-1-01
6 · The paper itself

Abstract

Efficiently exploring organic molecules through multi-step processes demands a transition from conventional laboratory synthesis to automated systems. Existing platforms for machine-assistant synthetic workflows compatible with multiple liquid-phases require substantial engineering investments for setup, thereby hindering quick customization and throughput increasement. Here we present a droplet-based chip that facilitates the self-organization of various liquid phases into stacked layers for conducting chemical transformations. The chip's precision polymer printing capability, enabled by digital micromirror device (DMD)-maskless photolithography and dual post-chemical modifications, allows it to create customized, sub-10 µm featured patterns to confine diverse liquids, regardless of density, within each droplet. The robustness and open design of surface-templated liquid layers actualize machine-assistant droplet manipulation, synchronous reaction triggering, local oscillation, and real-time monitoring of individual layers into a reality. We propose that, with further integration of machine operation line and self-learning, this droplet-based platform holds the potential to become a valuable addition to the toolkit of chemistry process, operating autonomously and with high-throughput.

Identifiers

PMID39117641
PMCPMC11310347

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.