ArticleThe British journal of ophthalmology2024
Central corneal thickness and the risk of primary open-angle glaucoma: a Mendelian randomisation mediation analysis.
Article in The British journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A clinical prediction tool for ocular hypertension following silicone oil tamponade in rhegmatogenous retinal detachment.BMC ophthalmology · 2026Article
- Precision of Pachymetry Measured With a Portable High-Resolution Ultrasound, a Standard Ultrasound, and Two Scheimpflug Pachymeters.Journal of ophthalmology · 2026Article
- Immune-gut-metabolite Interactions in Multiple Sclerosis: A Mendelian Randomization and Mediation Study.Current neurovascular research · 2026Article
- Causal relationships between 41 inflammatory cytokines and myopia: a Mendelian randomization study.International journal of ophthalmology · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundThe association of central corneal thickness (CCT) with primary open-angle glaucoma (POAG) remains uncertain. Although several observational studies assessing this relationship have reported an inverse association between CCT and POAG, this could be the result of collider bias. In this study, we leveraged human genetic data to assess through Mendelian randomisation (MR) the effect of CCT on POAG risk and whether this effect is mediated by intraocular pressure (IOP) changes.
methodsWe used 24 single-nucleotide polymorphisms (SNPs) associated with CCT (p value<5×10
resultsMR analysis suggested a positive association between CCT and POAG (OR of POAG per 50 µm increase in CCT: 1.38; 95% CI: 1.18 to 1.61; p value<0.01). MR mediation analysis showed that 28.4% of the total effect of CCT on POAG risk was mediated through changes in IOP. The primary results were consistent with estimates of pleiotropy-robust MR methods.
conclusionContrary to most observational studies, our results showed that a higher CCT is associated with an increased risk of POAG.
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