Evidence map›Paper›PMID 39117313›Full record

ArticleUltraschall in der Medizin (Stuttgart, Germany : 1980)2025

Understanding confounding factors allows for accurate interpretation of liver stiffness measurements by ElastQ, a novel 2D shear wave elastography technique.

David Jm Bauer, Annalisa De Silvestri, Laura Maiocchi, Ambra Raimondi, Ruxandra Mare, Mattias Mandorfer, Ioan Sporea, Theresa Müllner-Bucsics, Giovanna Ferraioli, Thomas Reiberger

Abstract readMulticenter Study
In one paragraph

Article in Ultraschall in der Medizin (Stuttgart, Germany : 1980), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David Jm BauerDivision of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-9363-8518
Annalisa De SilvestriClinical Epidemiology and Biometric Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Laura MaiocchiClinical Sciences and Infectious Diseases Department, Fondazione IRCCS Policlinico San Matteo, Medical School University of Pavia, Pavia, Italy.
Ambra RaimondiClinical Sciences and Infectious Diseases Department, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy, Pavia, Italy.
Ruxandra MareDepartment of Internal Medicine II, Division of Gastroenterology & Hepatology, Center for Advanced Research in Gastroenterology and Hepatology, "Victor Babes" University of Medicine and Pharmacy Timisoara, Timisoara, Romania.
Mattias MandorferDivision of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.
Ioan SporeaDepartment of Internal Medicine II, Division of Gastroenterology & Hepatology, Center for Advanced Research in Gastroenterology and Hepatology, "Victor Babes" University of Medicine and Pharmacy Timisoara, Timisoara, Romania.
Theresa Müllner-BucsicsDivision of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.
Giovanna FerraioliInfectious Diseases, Fondazione IRCCS Policlinico S. Matteo, Medical School, University of Pavia, Pavia, Italy.ORCID 0000-0002-6344-697X
Thomas ReibergerInternal Medicine III, Div. of Gastroenterology & Hepatology, Medical University of Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver stiffness measurement (LSM) using vibration-controlled transient elastography (VCTE) or two-dimensional shear wave elastography (2D-SWE) is recommended to assess the risk of liver fibrosis and advanced chronic liver disease. Even though both techniques measure liver stiffness, their numerical results often diverge. Confounders and reliability criteria for 2D-SWE have not been systematically investigated.We prospectively recruited participants with paired LSM by VCTE and the novel 2D-SWE technique ElastQ (Philips) in three European tertiary centers. The following parameters were recorded: sex, age, body mass index (BMI), etiology, laboratory markers of liver damage and function, as well as cholestasis, LSM by VCTE and controlled attenuation parameter (CAP), interquartile range (IQR)/median for VCTE-LSM and ElastQ-LSM, and the skin-to-liver capsule distance.We included 840 participants: 447 (53.2%) males; median age 57.0 [IQR:19.0] years; median BMI 25.4 [6.0] kg/m

Indexed as

Elasticity Imaging TechniquesLiverLiver CirrhosisAdultAgedBody Mass IndexFemaleHumansMaleMiddle AgedProspective StudiesReproducibility of Results

Identifiers

PMID39117313
PMCPMC12329696

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.