Evidence map›Paper›PMID 39117271›Full record

ArticleThe journal of allergy and clinical immunology. In practice2024

Characterization and Incidence of Sunflower Seed Allergy in a Pediatric Allergy Clinic.

Elsa R Treffeisen, Claire Mepyans, Ellen R Conroy, Heather J Baer, David N Williams, Kathryn A Williams, Lynda C Schneider

Abstract read
In one paragraph

Article in The journal of allergy and clinical immunology. In practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Hospital-Based Food Challenges for the Diagnosis of Food Allergy-A BSACI Clinical Practice Statement.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Guideline
  2. Oral immunotherapy for the treatment of pumpkin seed allergy: a real-world case series.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elsa R TreffeisenDivision of Immunology, Boston Children's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass. Electronic address: elsa.treffeisen@childrens.harvard.edu.
Claire MepyansWarren Alpert Medical School of Brown University, Providence, RI.
Ellen R ConroyDivision of Immunology, Boston Children's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.
Heather J BaerHarvard Medical School, Boston, Mass; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass; Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, Mass.
David N WilliamsBiostatistics and Research Design Center, ICCTR, Boston Children's Hospital, Boston, Mass.
Kathryn A WilliamsBiostatistics and Research Design Center, ICCTR, Boston Children's Hospital, Boston, Mass.
Lynda C SchneiderDivision of Immunology, Boston Children's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.

Funding

MOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI Janet Chou, Peter A Nigrovic · 1996 to 2026
$13.1M
NIAID NIH HHS T32 AI007512
6 · The paper itself

Abstract

backgroundSunflower seeds are a popular allergen-free peanut alternative.

objectiveTo describe sunflower seed allergy incidence and characteristics.

methodsWe conducted a retrospective cohort study of patients with sunflower seed allergy from 1995 to 2021 in a pediatric allergy clinic. We described demographic characteristics, testing results, atopic comorbidities, and reaction histories of patients with sunflower seed allergy and calculated the annual cumulative incidence of the allergy. Logistic regression was used to estimate the increase in odds of sunflower seed allergy diagnosis for each year from 1995 to 2021.

resultsFrom 1995 to 2021, we identified 235 patients with sunflower seed allergy. Among patients with sunflower seed allergy, the median age at diagnosis was 3.9 years. More than three-quarters of patients had another atopic condition. Half of the reactions consisted of mild urticaria or rash, and a quarter met criteria for anaphylaxis. The cumulative incidence ranged from 0% (1995-1999, 2001-2004, and 2006) to 0.38% (2021). From 1995 to 2021, the odds of sunflower seed allergy diagnosis increased annually by 21% (odds ratio, 1.21; 95% CI, 1.17-1.25).

conclusionsIn our single-center cohort of children with sunflower seed allergy, most children were diagnosed in early childhood, had high rates of comorbid atopic conditions, and had high rates of cutaneous reactions to sunflower seed products. Moreover, in our cohort, incidence of sunflower seed allergy increased.

Indexed as

Food HypersensitivityHelianthusSeedsAdolescentAllergensAnaphylaxisChildChild, PreschoolFemaleHumansIncidenceInfantMaleRetrospective StudiesAllergensFood allergyIncidencePediatricSeed allergySunflower allergySunflower seedSunflower seed allergy

Identifiers

PMID39117271
PMCPMC11560651

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.