Evidence map›Paper›PMID 39116913›Full record

ArticleAnnals of clinical and translational neurology2024

Socioeconomic status moderates associations between hippocampal development and cognition in preterms.

Julia Konrad, Ting Guo, Steven Ufkes, Thiviya Selvanathan, Min Sheng, Eiman Al-Ajmi, Helen M Branson, Vann Chau, Linh G Ly, Edmond N Kelly and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Julia KonradDepartment of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.ORCID 0009-0002-8454-7363
Ting GuoDepartment of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Steven UfkesDepartment of Pediatrics, BC Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Thiviya SelvanathanDepartment of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Min ShengNeurosciences & Mental Health, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Eiman Al-AjmiDepartment of Diagnostic Imaging, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Helen M BransonDepartment of Diagnostic Imaging, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Vann ChauDepartment of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Linh G LyDepartment of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Edmond N KellyDepartment of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Ruth E GrunauDepartment of Pediatrics, BC Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Steven P MillerDepartment of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.

Funding

B. Braun FoundationBloorview Children's Hospital Foundation Chair in Pediatric NeuroscienceBrain CanadaCerebral Palsy Alliance PG-016817Children's Hospital Dritter OrdenCIHR MOP-136966CIHR PJT-168894CIHR Canada Graduate ScholarshipsHudson Family Hospital Chair in Pediatric MedicineJames & Annabel McCreary Chair in PediatricsOntario Brain Insitute (OBI)Ontario Ministry of Health-University of Toronto Clinician Investigator ProgramSickKids Research Institute Clinician Scientist Training Program
6 · The paper itself

Abstract

objectiveThe hippocampus plays a critical role in cognitive networks. The anterior hippocampus is vulnerable to early-life stress and socioeconomic status (SES) with alterations persisting beyond childhood. How SES modifies the relationship between early hippocampal development and cognition remains poorly understood. This study examined associations between SES, structural and functional development of neonatal hippocampus, and 18-month cognition in very preterm neonates.

methodsIn total, 179 preterm neonates were followed prospectively. Structural and resting-state functional MRI were obtained early-in-life and at term-equivalent age (median 32.9 and 41.1 weeks post-menstrual age) to calculate anterior and posterior hippocampal volumes and hippocampal functional connectivity strength. Eighteen-month cognition was assessed via Bayley-III. Longitudinal statistical analysis using generalized estimating equations, accounting for birth gestational age, post-menstrual age at scan, sex, and motion, was performed.

resultsSES, measured as maternal education level, modified associations between anterior but not posterior hippocampal volumes and 18-month cognition (interaction term p = 0.005), and between hippocampal connectivity and cognition (interaction term p = 0.05). Greater anterior hippocampal volumes and hippocampal connectivity were associated with higher cognitive scores only in the lowest SES group. Maternal education alone did not predict neonatal hippocampal volume from early-in-life and term.

interpretationSES modified the relationship between neonatal hippocampal development and 18-month cognition in very preterm neonates. The lack of direct association between maternal education and neonatal hippocampal volumes indicates that socio-environmental factors beyond the neonatal period contribute to modifying the relationship between hippocampal development and cognition. These findings point toward opportunities to more equitably promote optimal neurodevelopmental outcomes in very preterm infants.

Indexed as

CognitionHippocampusInfant, PrematureMagnetic Resonance ImagingSocial ClassChild DevelopmentFemaleHumansInfantInfant, Extremely PrematureInfant, NewbornLongitudinal StudiesMale

Identifiers

PMID39116913
PMCPMC11537128

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.