Evidence map›Paper›PMID 39116883›Full record

ArticleCell reports methods2024

Development of a 3-dimensional organotypic model with characteristics of peripheral sensory nerves.

Madoka Koyanagi, Ryosuke Ogido, Akari Moriya, Mamiko Saigo, Satoshi Ihida, Tomoko Teranishi, Jiro Kawada, Tatsuya Katsuno, Kazuo Matsubara, Tomohiro Terada and 2 more

Abstract read
In one paragraph

Article in Cell reports methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. [Generation of induced pluripotent stem cells from peripheral blood mononuclear cells of a patient with autosomal recessive CharcotZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Article
  4. Roles of abioRxiv : the preprint server for biology · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Madoka KoyanagiDepartment of Medical Neuropharmacology, School of Pharmaceutical Sciences, Wakayama Medical University, Wakayama 640-8156, Japan.
Ryosuke OgidoDepartment of Clinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Akari MoriyaDepartment of Clinical Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Mamiko SaigoDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto 606-8507, Japan.
Satoshi IhidaNew Business Promotion Division, Business Development Unit, Panel Semicon Laboratories, Sharp Corporation, Tenri, Nara 632-8567, Japan.
Tomoko TeranishiNew Business Promotion Division, Business Development Unit, Panel Semicon Laboratories, Sharp Corporation, Tenri, Nara 632-8567, Japan.
Jiro KawadaJiksak Bioengineering, Inc., Kawasaki, Kanagawa 210-0821, Japan.
Tatsuya KatsunoDivision of Electron Microscopic Study, Center for Anatomical Studies, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Kazuo MatsubaraSchool of Pharmaceutical Sciences, Wakayama Medical University, Wakayama 640-8156, Japan.
Tomohiro TeradaDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto 606-8507, Japan.
Akira YamashitaDepartment of Medical Neuropharmacology, School of Pharmaceutical Sciences, Wakayama Medical University, Wakayama 640-8156, Japan.
Satoshi ImaiDepartment of Medical Neuropharmacology, School of Pharmaceutical Sciences, Wakayama Medical University, Wakayama 640-8156, Japan; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto 606-8507, Japan. Electronic address: imais06@wakayama-med.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We developed a rat dorsal root ganglion (DRG)-derived sensory nerve organotypic model by culturing DRG explants on an organoid culture device. With this method, a large number of organotypic cultures can be produced simultaneously with high reproducibility simply by seeding DRG explants derived from rat embryos. Unlike previous DRG explant models, this organotypic model consists of a ganglion and an axon bundle with myelinated A fibers, unmyelinated C fibers, and stereo-myelin-forming nodes of Ranvier. The model also exhibits Ca

Indexed as

AxonsGanglia, SpinalMicrophysiological SystemsActivating Transcription Factor 3AnimalsCalcium SignalingMyelin SheathOrganoidsPeripheral NervesRatsRats, Sprague-DawleySensory Receptor CellsActivating Transcription Factor 3Atf3 protein, ratCP: Neuroscienceex vivo explant culturemicrofluidic devicemyelinnerve regenerationnode of Ranvierorganotypic modelperipheral nervous systemperipheral neuropathySchwann cellssensory nerve

Identifiers

PMID39116883
PMCPMC11384078

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.