Evidence map›Paper›PMID 39116352›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

A Complementary Dual-Mode Ion-Electron Conductive Hydrogel Enables Sustained Conductivity for Prolonged Electroencephalogram Recording.

Hengjie Su, Linna Mao, Xiaoqi Chen, Peishuai Liu, Jiangbo Pu, Zhuo Mao, Tomoko Fujiwara, Yue Ma, Xinyang Mao, Ting Li

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Photopatternable PEDOT:PSS Hydrogels for High-Resolution Photolithography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hengjie SuInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China.
Linna MaoInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China.ORCID 0000-0001-7254-1613
Xiaoqi ChenInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China.
Peishuai LiuInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China.
Jiangbo PuInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China.
Zhuo MaoInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China.
Tomoko FujiwaraDepartment of Chemistry, The University of Memphis, Memphis, TN, 38152, USA.
Yue MaInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China.
Xinyang MaoDepartment of Biomedical Engineering, Tianjin Medical University, Tianjin, 301700, China.
Ting LiInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China.ORCID 0000-0001-5145-3024

Funding

Chinese Academy of Medical Science health innovation project 2021-I2M-1-058 2021-I2M-1-042Fundamental Research Funds for the Central Universities 3332023070Key Project of Construction of Drug Regulatory Science System RS2024×007National Natural Science Foundation of China 32301131STI 2030-Major Projects 2021ZD0200406Tianjin Outstanding Youth Fund Project 20JCJQIC00230
6 · The paper itself

Abstract

Conductive gel interface materials are widely employed as reliable agents for electroencephalogram (EEG) recording. However, prolonged EEG recording poses challenges in maintaining stable and efficient capture due to inevitable evaporation in hydrogels, which restricts sustained high conductivity. This study introduces a novel ion-electron dual-mode conductive hydrogel synthesized through a cost-effective and streamlined process. By embedding graphite nanoparticles into ionic hyaluronic acid (HAGN), the hydrogel maintains higher conductivity for over 72 h, outperforming commercial gels. Additionally, it exhibits superior low skin contact impedance, considerable electrochemical capability, and excellent tensile and adhesion performance in both dry and wet conditions. The biocompatibility of the HAGN hydrogel, verified through in vitro cell viability assays and in vivo skin irritation tests, underscores its suitability for prolonged skin contact without eliciting adverse reactions. Furthermore, in vivo EEG tests confirm the HAGN hydrogel's capability to provide high-fidelity signal acquisition across multiple EEG protocols. The HAGN hydrogel proves to be an effective interface for prolonged high-quality EEG recording, facilitating high-performance capture and classification of evoked potentials, thereby providing a reliable conductive medium for EEG-based systems.

Indexed as

Electric ConductivityElectroencephalographyHydrogelsAnimalsGraphiteHumansHyaluronic AcidNanoparticlesRatsGraphiteHyaluronic AcidHydrogelsconductive hydrogeldual‐mode conducting mechanismelectroencephalogram (EEG)graphite nanoparticleshyaluronic acid

Identifiers

PMID39116352
PMCPMC11481220

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.