Evidence map›Paper›PMID 39116305›Full record

ArticleChemMedChem2024

Higher Order Structure Differences Among Insulin Crystalline Drugs Revealed by 2D heteronuclear NMR.

Songlin Wang, Chad M Rienstra, Kang Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Methyl Proton Spin Relaxation (Analytical chemistry · 2026
    Article
  2. Other Techniques.Advances in biochemical engineering/biotechnology · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Songlin WangNational Magnetic Resonance Facility at Madison (NMRFAM), University of Wisconsin-Madison, Madison, WI-53706, United States.ORCID 0000-0002-7588-7377
Chad M RienstraNational Magnetic Resonance Facility at Madison (NMRFAM), University of Wisconsin-Madison, Madison, WI-53706, United States.ORCID 0000-0002-9912-5596
Kang ChenOffice of Pharmaceutical Quality Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD-20993, United States.ORCID 0000-0003-0276-2474

Funding

NMR User Program at NMRFAMR24GM141526 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine Anne Henzler-Wildman · 2021 to 2026
$6.4M
NIGMS NIH HHS R24 GM141526NIH HHS R24GM141526
6 · The paper itself

Abstract

During therapeutic protein development, two-dimensional (2D) heteronuclear NMR spectra can be a powerful analytical method for measuring protein higher order structure (HOS) in solution since the spectra exhibit much higher resolution than homonuclear

Indexed as

InsulinCrystallizationHumansMolecular StructureNuclear Magnetic Resonance, BiomolecularInsulinDrug quality assessmentHigher order structure characterizationInsulin NPH crystalProtein structureSolid-state NMR

Identifiers

PMID39116305
PMCPMC12112445

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.