Evidence map›Paper›PMID 39116217›Full record

ArticleScience (New York, N.Y.)2024

Giant polyketide synthase enzymes in the biosynthesis of giant marine polyether toxins.

Timothy R Fallon, Vikram V Shende, Igor H Wierzbicki, Amanda L Pendleton, Nathan F Watervoort, Robert P Auber, David J Gonzalez, Jennifer H Wisecaver, Bradley S Moore

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Systematic Review: Long-Read Sequencing in Algal Studies.International journal of molecular sciences · 2026
    Pooled it
  2. Marine natural products.Natural product reports · 2026
    Review
  3. Article
  4. Design principles imprinted by evolution.Nature chemical biology · 2025
    Article
  5. Article
  6. Article
  7. Bioactive Polyketides fromMarine drugs · 2025
    Review
  8. The Chemistry of Phytoplankton.Chemical reviews · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Timothy R Fallon *Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3048-7679
Vikram V Shende *Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-8396-6297
Igor H WierzbickiDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0009-0004-1441-3233
Amanda L PendletonDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-7201-0596
Nathan F WatervoortDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-5227-4818
Robert P AuberDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-1442-7473
David J GonzalezDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-1423-5970
Jennifer H WisecaverDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
Bradley S MooreCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-4652-1253

Funding

Natural Product Genome MiningR01GM085770 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JENSEN, PAUL R, MOORE, BRADLEY S · 2009 to 2024
$5.8M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
Elucidating the Biosynthesis of a Model Ladder-Frame Polyether ToxinF32ES032276 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FALLON, TIMOTHY R · 2020 to 2023
$220k
Refactoring Soft Coral Diterpenoid BiosynthesisF32GM145146 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHENDE, VIKRAM VIJAY · 2022 to 2024
$215k
NIEHS NIH HHS F32 ES032276NIGMS NIH HHS F32 GM145146NIGMS NIH HHS R01 GM085770NIH HHS S10 OD026929
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HaptophytaPolyether ToxinsPolyketide SynthasesPolyenesPolyketidesProtein DomainsPolyenesPolyether ToxinsPolyketidesPolyketide Synthases

Identifiers

PMID39116217
PMCPMC11416037

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.