Evidence map›Paper›PMID 39116209›Full record

ArticleCell reports2024

Synaptotagmins 3 and 7 mediate the majority of asynchronous release from synapses in the cerebellum and hippocampus.

Dennis J Weingarten, Amita Shrestha, Daniel J Orlin, Chloé L Le Moing, Luke A Borchardt, Skyler L Jackman

Abstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies.Annals of clinical and translational neurology · 2026
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dennis J WeingartenVollum Institute, Oregon Health & Science University, Portland, OR, USA.
Amita ShresthaVollum Institute, Oregon Health & Science University, Portland, OR, USA.
Daniel J OrlinVollum Institute, Oregon Health & Science University, Portland, OR, USA.
Chloé L Le MoingVollum Institute, Oregon Health & Science University, Portland, OR, USA.
Luke A BorchardtVollum Institute, Oregon Health & Science University, Portland, OR, USA.
Skyler L JackmanVollum Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address: jackmans@ohsu.edu.

Funding

Ultrastructure and Single Particle Microscopy CoreP30NS061800 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A · 2009 to 2020
$6.6M
The mechanisms and functions of short-term synaptic plasticityR01NS135048 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Skyler Lofstrand Jackman · 2024 to 2026
$1.3M
NINDS NIH HHS P30 NS061800NINDS NIH HHS R01 NS135048
6 · The paper itself

Abstract

Neurotransmitter release consists of rapid synchronous release followed by longer-lasting asynchronous release (AR). Although the presynaptic proteins that trigger synchronous release are well understood, the mechanisms for AR remain unclear. AR is sustained by low concentrations of intracellular Ca

Indexed as

CerebellumHippocampusMice, KnockoutSynapsesSynaptotagminsAnimalsCalciumMiceMice, Inbred C57BLSynaptic TransmissionCalciumSynaptotagminsSyt7 protein, mouseasynchronous releasecerebellumCP: Neurosciencehippocampusplasticitysynaptic transmissionsynaptotagmin

Identifiers

PMID39116209
PMCPMC11410144

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.