Evidence map›Paper›PMID 39116124›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

R-loop functions in

Huai-Chin Chiang, Leilei Qi, Payal Mitra, Yimeng Huang, Yanfen Hu, Rong Li

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. R-loops: a key driver of inflammatory responses in cancer.Experimental & molecular medicine · 2025
    Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Huai-Chin ChiangDepartment of Biochemistry and Molecular Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC 20037.ORCID 0000-0002-7616-3362
Leilei QiDepartment of Anatomy and Cell Biology, School of Medicine & Health Sciences, The George Washington University, Washington, DC 20037.
Payal MitraDepartment of Biochemistry and Molecular Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC 20037.
Yimeng HuangDepartment of Biochemistry and Molecular Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC 20037.ORCID 0009-0005-5179-1724
Yanfen HuDepartment of Anatomy and Cell Biology, School of Medicine & Health Sciences, The George Washington University, Washington, DC 20037.ORCID 0000-0001-9595-1631
Rong LiDepartment of Biochemistry and Molecular Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC 20037.

Funding

T Cell-Specific BRCA1 Function in Antitumor Immunity and ImmunotherapyR01CA282303 · NCI · GEORGE WASHINGTON UNIVERSITY · PI YANFEN HU, Rong Li · 2023 to 2026
$2.4M
Crosstalk between BRCA1 and Transcription in Breast CancerR01CA220578 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LI, RONG · 2017 to 2022
$2.1M
Role of BRCA1 phosphorylation in DNA DSB repair and genome stability maintenanceR01CA212674 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HU, YANFEN, LI, RONG · 2017 to 2022
$1.9M
HHS | NIH (NIH) R01CA212674HHS | NIH (NIH) R01CA220578HHS | NIH (NIH) R01CA282303NCI NIH HHS R01 CA212674NCI NIH HHS R01 CA220578NCI NIH HHS R01 CA282303
6 · The paper itself

Abstract

Deleterious accumulation of R-loops, a DNA-RNA hybrid structure, contributes to genome instability. They are associated with

Indexed as

BRCA1 ProteinCarcinogenesisR-Loop StructuresAnimalsBreast NeoplasmsDNA ReplicationEstrogen Receptor alphaFemaleGenomic InstabilityHumansMammary Neoplasms, AnimalMiceBRCA1 ProteinBrca1 protein, mouseEstrogen Receptor alphaBRCA1mouse geneticsR-loopstumorigenesis

Identifiers

PMID39116124
PMCPMC11331088

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.