Evidence map›Paper›PMID 39115644›Full record

ArticleCell biochemistry and biophysics2024

Navigating the Fractional Calcium Dynamics of Orai Mechanism in Polar Dimensions.

Brajesh Kumar Jha, Vora Hardagna Vatsal, Tajinder Pal Singh

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Article in Cell biochemistry and biophysics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brajesh Kumar JhaDepartment of Mathematics, School of Technology, Pandit Deendayal Energy University, Gandhinagar, Gujarat, India.
Vora Hardagna VatsalDepartment of Mathematics, School of Technology, Pandit Deendayal Energy University, Gandhinagar, Gujarat, India. hardagna.vora@gmail.com.
Tajinder Pal SinghDepartment of Mathematics, School of Technology, Pandit Deendayal Energy University, Gandhinagar, Gujarat, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium plays a crucial role as a second messenger in neuronal signal transduction pathways. The influx of calcium ions through various physicochemical gating channels activates neuronal calcium signaling. The Endoplasmic Reticulum (ER) is a significant intracellular structure that sequesters calcium and controls signaling through SERCA, IPR, and leak channel mechanisms. Disruption of calcium dynamics can trigger intrinsic dyshomeostasis, cell damage, and apoptosis. The present study articulates a Caputo fractional time derivative in the polar coordinate dimensions to investigate the role of nonlocal calcium-free ions in the neuron through the Orai channel, and ER fluxes, incorporating various physiological parameters. The solution was obtained through the hybrid integral transform technique for analytical form. The closed form was generated using Green's function in terms of Mainardi and Wright's functions. Our simulation uncovered the calcium concentration bandwidth of interaction with different neuronal parameters. Parameters and calcium ion synergy show normal and Alzheimer's disease-impacted interaction through different illustrations. Our simulation reveals that S100B and BAPTA have significant calcium-controlling behavior.

Indexed as

CalciumEndoplasmic ReticulumAlzheimer DiseaseCalcium SignalingHumansNeuronsORAI1 ProteinS100 Calcium Binding Protein beta SubunitCalciumORAI1 ProteinS100 Calcium Binding Protein beta SubunitAlzheimer’s diseaseCalcium ionsFractional-order derivativeNeuron

Identifiers

PMID39115644

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.