Evidence map›Paper›PMID 39115608›Full record

Observational studyClinical research in cardiology : official journal of the German Cardiac Society2025

Community-based analysis of stroke prevention and effect of public interventions in atrial fibrillation: results from the ARENA project.

Maura M Zylla, Belgin Özdemir, Matthias Hochadel, U Zeymer, Ibrahim Akin, Armin Grau, Steffen Schneider, Angelika Alonso, Bernd Waldecker, Tim Süselbeck and 7 more

Registry-linked trialAbstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02978248 (Af Register RhEin NeckAr - Projekt Vorhofflimmern Rhein Neckar), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02978248 completednot on this map

Af Register RhEin NeckAr - Projekt Vorhofflimmern Rhein Neckar

Typeobservational_patient_registrySponsorStiftung Institut fuer HerzinfarktforschungRan2016 to 2021Enrolled2,777ConditionsAtrial Fibrillation
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Cardiac sarcoidosis in patients with recurrent ventricular arrhythmias refractory to endocardial ablation.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Maura M ZyllaDepartment of Cardiology, University of Heidelberg, Medical University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. maura.zylla@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0001-9373-8132
Belgin ÖzdemirStiftung Institut für Herzinfarktforschung, IHF, Bremserstraße 79, 67063, Ludwigshafen, Germany.
Matthias HochadelStiftung Institut für Herzinfarktforschung, IHF, Bremserstraße 79, 67063, Ludwigshafen, Germany.
U ZeymerStiftung Institut für Herzinfarktforschung, IHF, Bremserstraße 79, 67063, Ludwigshafen, Germany.
Ibrahim AkinDZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, 69120, Heidelberg, Germany.
Armin GrauDepartment of Neurology, Hospital Ludwigshafen, Bremserstraße 79, 67063, Ludwigshafen, Germany.
Steffen SchneiderStiftung Institut für Herzinfarktforschung, IHF, Bremserstraße 79, 67063, Ludwigshafen, Germany.
Angelika AlonsoDepartment of Neurology, University Medical Center Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Bernd WaldeckerDepartment of Cardiology and Angiology, GRN Klinikum Schwetzingen, Bodelschwinghstr. 10, 68723, Schwetzingen, Germany.
Tim SüselbeckKardiologische Praxisklinik, 67071, Ludwigshafen, Germany.
Harald SchwackeDiakonissen-Stiftungs-Krankenhaus Speyer, 67346, Speyer, Germany.
Markus HaassTheresienkrankenhaus Mannheim, Bassermannstraße 1, 68165, Mannheim, Germany.
Ralf ZahnDepartment of Cardiology, Hospital Ludwigshafen, Bremserstraße 79, 67063, Ludwigshafen, Germany.
Martin BorggrefeDZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, 69120, Heidelberg, Germany.
Jochen SengesStiftung Institut für Herzinfarktforschung, IHF, Bremserstraße 79, 67063, Ludwigshafen, Germany.
Norbert FreyDepartment of Cardiology, University of Heidelberg, Medical University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Dierk ThomasDepartment of Cardiology, University of Heidelberg, Medical University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCommunity-based interventions may promote awareness and adherence to atrial fibrillation (AF)-related therapies, potentially reducing adverse events. The ARENA project investigated the health status, therapies and events in AF patients in the Rhein-Neckar Region, Germany. The subproject "ARENA intervention" studied the effect of community-based interventions on AF-associated outcomes.

methodsFrom 2016 onward, patients with diagnosed AF were recruited for the observational ARENA registry. In 2018, an intervention period was initiated involving population-based information campaigns on AF diagnosis and therapies. The "control group" was recruited prior to initiation, and the "intervention group" afterward. Patients underwent standardized follow-up > 1 year after recruitment. Clinical outcomes, therapy and quality of life were compared between the two groups.

resultsA total of 2769 patients were included. This real-world cohort showed high adherence to oral anticoagulation therapy (OAC) and an increased use of NOACs over vitamin K antagonists over time. In the intervention group (n = 1362), more patients continued OAC at follow-up (87.1% vs. 81.5%, P = 0.002). However, this difference was not significant in the patient subgroup with class I/IIa indications for OAC (90.1% vs. 87.5%, P = 0.11). AF-related re-hospitalization was lower in the intervention group (6.8% vs. 12.3%, P < 0.001). There was no significant difference in quality of life. AF-related anxiety was reduced at follow-up. Of note, nearly a quarter of all patients stated that ARENA had influenced their health perception.

conclusionTailored community-based campaigns may raise awareness for AF-related health issues, supporting therapy adherence. Future public strategies to improve quality of life in AF patients should be investigated, as the ARENA project hints at a potential benefit of population-based campaigns.

trial registrationClinicalTrials.gov (Identifier: NCT02978248).

Indexed as

AnticoagulantsAtrial FibrillationQuality of LifeStrokeAgedAged, 80 and overFemaleFollow-Up StudiesGermanyHumansMaleMiddle AgedRegistriesAnticoagulantsAtrial fibrillationCommunity-based interventionOral anticoagulationPatient-reported outcomesQuality of life

Identifiers

PMID39115608
PMCPMC11772519

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.