Evidence map›Paper›PMID 39115381›Full record

ArticleACS synthetic biology2024

Engineering a Novel Probiotic Toolkit in

Nathalie Weibel, Martina Curcio, Atilla Schreiber, Gabriel Arriaga, Marine Mausy, Jana Mehdy, Lea Brüllmann, Andreas Meyer, Len Roth, Tamara Flury and 10 more

Abstract read
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Living Microbial Drugs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  5. Review
  6. Current and emerging approaches to manage chronic inflammatory gut disorders.Frontiers in cellular and infection microbiology · 2026
    Review
  7. Probiotic-Based Materials as Living Therapeutics.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Nathalie WeibelUniversity of Zürich, Campus Irchel Winterthurerstrasse 190, 8057 Zürich, Switzerland.ORCID 0009-0007-1930-5372
Martina CurcioUniversity of Zürich, Campus Irchel Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Atilla SchreiberUniversity of Zürich, Campus Irchel Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Gabriel ArriagaUniversity of Zürich, Campus Irchel Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Marine MausyUniversity of Zürich, Campus Irchel Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Jana MehdyUniversity of Zürich, Campus Irchel Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Lea BrüllmannUniversity of Zürich, Campus Irchel Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Andreas MeyerUniversity of Zürich, Campus Irchel Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Len RothUniversity of Zürich, Campus Irchel Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Tamara FluryUniversity of Zürich, Campus Irchel Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Valerie PecinaUniversity of Zürich, Campus Irchel Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Kim StarlingerUniversity of Zürich, Campus Irchel Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Jan DerničInstitute of Pharmacology and Toxicology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Kenny JungferDepartment of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Fabian AckleInstitute of Medical Microbiology, University of Zürich, Gloriastrasse 28/30, CH-8006 Zürich, Switzerland.ORCID 0000-0002-7199-5004
Jennifer EarpInstitute of Medical Microbiology, University of Zürich, Gloriastrasse 28/30, CH-8006 Zürich, Switzerland.
Martin HausmannDepartment of Gastroenterology and Hepatology, University Hospital Zürich and Zürich University, Rämistrasse 100, 8091 Zurich, Switzerland.
Martin JinekDepartment of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Gerhard RoglerDepartment of Gastroenterology and Hepatology, University Hospital Zürich and Zürich University, Rämistrasse 100, 8091 Zurich, Switzerland.
Cauã Antunes WestmannDepartment of Evolutionary Biology and Environmental Studies, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.ORCID 0000-0003-1572-2279

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation with no cure and limited treatment options that often have systemic side effects. In this study, we developed a target-specific system to potentially treat IBD by engineering the probiotic bacterium

Indexed as

Escherichia coliInflammatory Bowel DiseasesProbioticsAdalimumabHumansInflammationNitric OxideSingle-Domain AntibodiesTumor Necrosis Factor-alphaAdalimumabNitric OxideSingle-Domain AntibodiesTumor Necrosis Factor-alphaE. coli Nissle 1917 (EcN)engineered probioticIBDinflammationnanobodiesnitric oxideTNFα

Identifiers

PMID39115381
PMCPMC11334186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.