Evidence map›Paper›PMID 39115219›Full record

ArticleJournal of medicinal chemistry2024

A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant

Sveva Pelliccia, Pasquale Russomanno, Simona Barone, Baptiste Mateu, Antonella Ilenia Alfano, Martina Miranda, Lorena Coretti, Francesca Lembo, Marialuisa Piccolo, Carlo Irace and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frontiers in pharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sveva PellicciaDepartment of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-5526-5554
Pasquale RussomannoMagnetic Resonance Centre (CERM), Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP) and Department of Chemistry "Ugo Schiff", University of Florence, Via L. Sacconi 6, Sesto Fiorentino 50019, Italy.
Simona BaroneDepartment of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.
Baptiste MateuDepartment of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.
Antonella Ilenia AlfanoDepartment of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.
Martina MirandaDepartment of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
Lorena CorettiDepartment of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.
Francesca LemboDepartment of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.
Marialuisa PiccoloBioChemLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.
Carlo IraceBioChemLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.
Laura FriggeriDepartment of Cell and Development Biology, U4225 Medical Research Building III, 465 21st Avenue South Room 4160 MRB III Nashville, Tennessee 37232, United States.
Tatiana Y HargroveDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
Aaron CurtisDepartment of Biology, Maynooth University, W23 F2H6 Maynooth, Co. Kildare, Ireland.
Galina I LepeshevaDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0002-6975-1131
Kevin KavanaghDepartment of Biology, Maynooth University, W23 F2H6 Maynooth, Co. Kildare, Ireland.
Elisabetta BuomminoDepartment of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.
Margherita BrindisiDepartment of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0001-9119-3773

Funding

Structural requirements for sterol 14α-demethylasesR35GM151876 · NIGMS · VANDERBILT UNIVERSITY · PI Galina I Lepesheva · 2024 to 2026
$1.1M
NIGMS NIH HHS R35 GM151876
6 · The paper itself

Abstract

The widespread and irrational use of azole antifungal agents has led to an increase of azole-resistant

Indexed as

Antifungal AgentsCandida albicansDrug Resistance, FungalIsoxazolesMicrobial Sensitivity TestsMolecular Docking SimulationPyrazolesVoriconazoleAnimalsAzolesCandidiasisDisease Models, AnimalDrug SynergismHumansMothsStructure-Activity RelationshipAntifungal AgentsAzolesIsoxazolesPyrazolesVoriconazole

Identifiers

PMID39115219
PMCPMC11482282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.