Evidence map›Paper›PMID 39115162›Full record

Trial reportThe Laryngoscope2024

Prospective Outcomes After Serial Platelet-Rich Plasma (PRP) Injection in Vocal Fold Scar and Sulcus.

Chloe Santa Maria, Elizabeth A Shuman, Benjamin Van Der Woerd, Clare Moffatt, Carlos X Castellanos, William Z Gao, Neel K Bhatt, Yael E Bensoussan, Jack Rodman, Kacie La Forest and 4 more

Abstract readMulticenter StudyClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Laryngoscope, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chloe Santa MariaUSC Voice Center, Caruso Department of Otolaryngology, Head and Neck Surgery, Keck School of Medicine, Los Angeles, California, U.S.A.ORCID 0009-0000-2734-3677
Elizabeth A ShumanUSC Voice Center, Caruso Department of Otolaryngology, Head and Neck Surgery, Keck School of Medicine, Los Angeles, California, U.S.A.ORCID 0009-0009-0872-869X
Benjamin Van Der WoerdDivision of Otolaryngology-Head & Neck Surgery, Department of Surgery, McMaster University, Ontario, Canada.ORCID 0000-0002-4189-2733
Clare MoffattDepartment of Otolaryngology-Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, U.S.A.ORCID 0000-0003-2794-9956
Carlos X CastellanosDepartment of Otolaryngology-Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, U.S.A.ORCID 0000-0002-3569-663X
William Z GaoUChicago Voice Center, Department of Surgery, Section of Otolaryngology-Head & Neck Surgery, University of Chicago, Chicago, Illinois, U.S.A.
Neel K BhattDivision of Laryngology, Department of Otolaryngology-Head & Neck Surgery, University of Washington School of Medicine, Seattle, Washington, USA.
Yael E BensoussanUSF Health Voice Center, Department of Otolaryngology - Head and Neck Surgery, University of Southern Florida, Tampa, Florida, USA.ORCID 0000-0002-1635-8627
Jack RodmanSouthern California Clinical and Translational Science Institute (SC CTSI), University of Southern California, Los Angeles, California, U.S.A.
Kacie La ForestUSC Voice Center, Caruso Department of Otolaryngology, Head and Neck Surgery, Keck School of Medicine, Los Angeles, California, U.S.A.
Felicia FrancoisUSC Voice Center, Caruso Department of Otolaryngology, Head and Neck Surgery, Keck School of Medicine, Los Angeles, California, U.S.A.
Karla O'DellUSC Voice Center, Caruso Department of Otolaryngology, Head and Neck Surgery, Keck School of Medicine, Los Angeles, California, U.S.A.
Dinesh K ChhetriDepartment of Otolaryngology-Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, U.S.A.
Michael M JohnsUSC Voice Center, Caruso Department of Otolaryngology, Head and Neck Surgery, Keck School of Medicine, Los Angeles, California, U.S.A.

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855Southern California Clinical and Translational Science Institute UL1TR000130Southern California Clinical and Translational Science Institute UL1TR001855
6 · The paper itself

Abstract

objectiveVocal fold scar and sulcus pose significant treatment challenges with no current optimal treatment. Platelet-rich plasma (PRP), an autologous concentration of growth factors, holds promise for regenerating the superficial lamina propria. This study aims to evaluate the potential benefits of serial PRP injections on mucosal wave restoration and vocal function.

methodsIn a prospective clinical trial across two institutions, patients with vocal fold scar underwent four serial PRP injections, one month apart. Blinded independent laryngologists and expert listeners used pretreatment and one-month post-fourth injection videostroboscopy and CAPE-V assessments to evaluate mucosal wave and voice quality changes, respectively. Additionally, patient reported outcome measures (PROMs) were evaluated.

resultsIn the study, 15 patients received 55 PRP injections without adverse effects. Eight patients (53.3%) had mild, three patients (20%) had moderate, and four patients (26.7%) had severe scar. There was an average reduction of 8.7 points in post-treatment VHI-10 scores (p = 0.007). The raters observed an improvement in post-treatment voice in 73.4% of cases, and CAPE-V scores showed a reduction of 18.8 points on average (p = 0.036). The videostroboscopic VALI ratings showed an improvement in mucosal wave rating from 2.0 to 4.0. On average, the raters perceived the post-PRP exams to be better in 56.7% of cases.

conclusionsPRP has been validated as a safe autologous option for treatment of vocal fold scar. While results for mucosal wave and voice quality varied, there was a consistent improvement in PROMs. LEVEL OF EVIDENCE: 3: Prospective cohort study, with blinded analysis Laryngoscope, 134:5021-5027, 2024.

Indexed as

CicatrixPlatelet-Rich PlasmaVocal CordsVoice QualityAdultAgedFemaleHumansInjectionsLaryngeal DiseasesMaleMiddle AgedPatient Reported Outcome MeasuresProspective StudiesStroboscopyTreatment Outcomeplatelet‐rich plasmasulcus vocalissuperficial lamina propria deficiencyvocal fold scarvocal fold sulcus

Identifiers

PMID39115162
PMCPMC11563877

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.