Evidence map›Paper›PMID 39115142›Full record

ArticleJournal of applied clinical medical physics2024

Validation of MLC leaf open time calculation methods for PSQA in adaptive radiotherapy with tomotherapy units.

Marie Nasrallah, François Bochud, Neelima Tellapragada, Jean Bourhis, Edward Chao, Dylan Casey, Raphaël Moeckli

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied clinical medical physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marie NasrallahInstitute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
François BochudInstitute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Neelima TellapragadaAccuray Incorporated, Madison, Wisconsin, USA.
Jean BourhisRadiation Oncology Department, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Edward ChaoAccuray Incorporated, Madison, Wisconsin, USA.
Dylan CaseyAccuray Incorporated, Madison, Wisconsin, USA.
Raphaël MoeckliInstitute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-5885-934X

Funding

Accuray Inc.
6 · The paper itself

Abstract

backgroundTreatment delivery safety and accuracy are essential to control the disease and protect healthy tissues in radiation therapy. For usual treatment, a phantom-based patient specific quality assurance (PSQA) is performed to verify the delivery prior to the treatment. The emergence of adaptive radiation therapy (ART) adds new complexities to PSQA. In fact, organ at risks and target volume re-contouring as well as plan re-optimization and treatment delivery are performed with the patient immobilized on the treatment couch, making phantom-based pretreatment PSQA impractical. In this case, phantomless PSQA tools based on multileaf collimator (MLC) leaf open times (LOTs) verifications provide alternative approaches for the Radixact® treatment units. However, their validity is compromised by the lack of independent and reliable methods for calculating the LOT performed by the MLC during deliveries. PURPOSE: To provide independent and reliable methods of LOT calculation for the Radixact® treatment units.

methodsTwo methods for calculating the LOTs performed by the MLC during deliveries have been implemented. The first method uses the signal recorded by the build-in detector and the second method uses the signal recorded by optical sensors mounted on the MLC. To calibrate the methods to the ground truth, in-phantom ionization chamber LOT measurements have been conducted on a Radixact® treatment unit. The methods were validated by comparing LOT calculations with in-phantom ionization chamber LOT measurements performed on two Radixact® treatment units.

resultsThe study shows a good agreement between the two LOT calculation methods and the in-phantom ionization chamber measurements. There are no notable differences between the two methods and the same results were observed on the different treatment units.

conclusionsThe two implemented methods have the potential to be part of a PSQA solution for ART in tomotherapy.

Indexed as

NeoplasmsOrgans at RiskPhantoms, ImagingQuality Assurance, Health CareRadiotherapy DosageRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedAlgorithmsHumansParticle Acceleratorsadaptive radiation therapy (ART)leaf open time (LOT)patient specific quality assurance (PSQA)tomotherapy

Identifiers

PMID39115142
PMCPMC11466468

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.