Evidence map›Paper›PMID 39115131›Full record

ArticleJournal of medicinal chemistry2024

(SiFA)SeFe: A Hydrophilic Silicon-Based Fluoride Acceptor Enabling Versatile Peptidic Radiohybrid Tracers.

Sandra Deiser, Sebastian Fenzl, Victor König, Marike Drexler, Lydia M Smith, Madeleine E George, Roswitha Beck, Timothy H Witney, Shigeyoshi Inoue, Angela Casini

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Comparison of twoEJNMMI radiopharmacy and chemistry · 2026
    Article
  7. Novel radiohybrid PET-Tracers for SSTEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sandra DeiserChair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, School of Natural Sciences, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching b. München, Germany.
Sebastian FenzlChair of Pharmaceutical Radiochemistry, Department of Chemistry, School of Natural Sciences, Technical University of Munich, Walther-Meißner-Str. 3, 85748 Garching b. München, Germany.ORCID 0009-0003-8710-4776
Victor KönigChair of Pharmaceutical Radiochemistry, Department of Chemistry, School of Natural Sciences, Technical University of Munich, Walther-Meißner-Str. 3, 85748 Garching b. München, Germany.ORCID 0009-0002-7106-3685
Marike DrexlerChair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, School of Natural Sciences, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching b. München, Germany.ORCID 0009-0007-8767-6028
Lydia M SmithSchool of Biomedical Engineering and Imaging Sciences King's College London St Thomas' Hospital, London SE1 7EH, U.K.
Madeleine E GeorgeSchool of Biomedical Engineering and Imaging Sciences King's College London St Thomas' Hospital, London SE1 7EH, U.K.
Roswitha BeckChair of Pharmaceutical Radiochemistry, Department of Chemistry, School of Natural Sciences, Technical University of Munich, Walther-Meißner-Str. 3, 85748 Garching b. München, Germany.
Timothy H WitneySchool of Biomedical Engineering and Imaging Sciences King's College London St Thomas' Hospital, London SE1 7EH, U.K.ORCID 0000-0002-9475-2873
Shigeyoshi InoueInstitute of Silicon Chemistry, Department of Chemistry, School of Natural Sciences, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching b. München, Germany.ORCID 0000-0001-6685-6352
Angela CasiniChair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, School of Natural Sciences, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching b. München, Germany.ORCID 0000-0003-1599-9542

Funding

Wellcome Trust 220221
6 · The paper itself

Abstract

The radiohybrid (rh) concept to design targeted (and chemically identical) radiotracers for imaging or radionuclide therapy of tumors has gained momentum. For this strategy, a new bifunctional Silicon-based Fluoride Acceptor (SiFA) moiety

Indexed as

Hydrophobic and Hydrophilic InteractionsReceptors, SomatostatinAnimalsCell Line, TumorChorioallantoic MembraneCoordination ComplexesFluoridesFluorine RadioisotopesHumansIron CompoundsLutetiumMicePeptidesPositron-Emission TomographyRadioisotopesRadiopharmaceuticalsCoordination ComplexesFluoridesFluorine-18Fluorine RadioisotopesIron CompoundsLutetiumLutetium-177PeptidesRadioisotopesRadiopharmaceuticalsReceptors, SomatostatinSiliconSSTR2 protein, human

Identifiers

PMID39115131
PMCPMC11345769

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.