ArticleStroke2024
Impact of Hypertension on the Dose-Response Association Between Physical Activity and Stroke: A Cohort Study.
Article in Stroke, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Impact of physical activity patterns on major adverse cardiovascular events in adults with hypertension.British journal of sports medicine · 2026Article
- Association of Physical Activity and Risk of Stroke: A Prospective Cohort Study of Chinese Middle-aged and Older Adults.Brain and behavior · 2026Article
- Association of physical activity with risk of major adverse cardiovascular events and mortality in Korean adults with hypertension.Clinical hypertension · 2026Article
- Exercise intensity and mortality in overweight and obese patients with chronic kidney disease: longitudinal analysis (1999-2016).BMC public health · 2024Article
- Comprehensive strategies for stroke prevention: A narrative review of population-level risk factor mitigation.Brain circulationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRegular physical activity is associated with a reduced stroke risk. However, this relationship might be attenuated in the presence of hypertension and antihypertensive medication use. We examined the dose-response relationship between physical activity and stroke in normotensive and hypertensive individuals.
methodsA Dutch population-based cohort including 139 930 individuals (41% men; mean age, 44±13) was performed (median follow-up, 6.75 years). Participants were stratified at baseline as hypertensive (44%) or normotensive (56%) and categorized into quartiles of the lowest (Q1) to the highest (Q4) moderate-to-vigorous, self-reported physical activity. The primary outcome was incident stroke (fatal and nonfatal). Cox regression estimated hazard ratios and 95% CIs. The main analyses were stratified on baseline blood pressure and adjusted for confounders. Hypertensives were stratified into medicated (21%) or non-medicated (79%).
resultsCompared with Q1, adjusted hazard ratios were 0.87 (0.69-1.10;
conclusionsRegular moderate-to-vigorous physical activity is beneficial for stroke risk reduction (Q3 compared with Q1), which is not affected by hypertension. Antihypertensive medication may be associated with a smaller benefit of moderate-to-vigorous physical activity on the risk of stroke, but further research is warranted.
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