Evidence map›Paper›PMID 39114836›Full record

ArticleClinical case reports2024

Adalimumab-induced leukocytoclastic vasculitis in a patient with ankylosing spondylitis: A case report.

Alireza Khabbazi, Mehrzad Hajialilo, Sepideh Tahsini Tekantapeh, Sahar Farshchi Tabrizi, Alireza Salehi

Abstract readCase Reports
In one paragraph

Article in Clinical case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alireza KhabbaziConnective Tissue Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran.ORCID https://orcid.org/0000-0002-9482-6967
Mehrzad HajialiloConnective Tissue Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran.
Sepideh Tahsini TekantapehDepartment of Rheumatology Student Research Committee, Tabriz University of Medical Sciences Tabriz Iran.ORCID https://orcid.org/0000-0003-2635-5793
Sahar Farshchi TabriziDepartment of Rheumatology Student Research Committee, Tabriz University of Medical Sciences Tabriz Iran.
Alireza SalehiTabriz University of Medical Science Tabriz Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical Key Message: In patients receiving anti-TNF-α drugs for ankylosing spondylitis, monitoring purpuric and ischemic skin lesions is crucial. This case underscores the significance of identifying and addressing drug-induced vasculitis while stressing the necessity for prompt evaluation and exploration of alternative treatment options to safeguard patient well-being. Abstract: The case discusses a 38-year-old female with a history of ankylosing spondylitis (AS) who presented with skin lesions, including purpuric skin lesions and ischemia of her right foot digits, after initiating treatment with adalimumab. After excluding other potential causes, such as infections and malignancies, the patient received a diagnosis of moderate-sized vascular vasculitis associated with adalimumab use. Discontinuation of adalimumab and treatment with high dose glucocorticoids and intravenous pulse of cyclophosphamide resulted in the resolution of her ischemic lesions. This case underscores the importance of considering drug-related side effects in patients with new skin lesions, particularly in the context of rheumatic diseases such as AS.

Indexed as

adalimumabankylosing spondylitisanti‐TNF‐α related vasculitisleukocytoclastic vasculitisnecrotizing vasculitispolyarteritis nodosa

Identifiers

PMID39114836
PMCPMC11305868

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.