Evidence map›Paper›PMID 39114821›Full record

ArticleFrontiers in medicine2024

Rationale and design of the multi organ inflammation with serial testing study: a comprehensive assessment of functional and structural abnormalities in patients with recovered COVID-19.

D Ian Paterson, James A White, Christian Beaulieu, Rachel Sherrington, Carla M Prado, Puneeta Tandon, Kieran Halloran, Stephanie Smith, Jennifer A McCombe, Bruce Ritchie and 9 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04525404 (MOIST Study), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04525404 completednot on this map

MOIST Study: Multi-Organ Imaging With Serial Testing in COVID-19 Infected Patients

TypeobservationalSponsorUniversity of AlbertaRan2020 to 2022Enrolled215ConditionsCovid19, Coronavirus Infection, SARS-CoV InfectionArmsMRI (heart, brain, lungs, liver), Bloodwork, Cognitive testing, Olfaction testing, Spirometry
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

D Ian PatersonUniversity of Ottawa Heart Institute, University of Ottawa, Ottawa, ON, Canada.
James A WhiteLibin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada.
Christian BeaulieuDepartment of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada.
Rachel SherringtonDepartment of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada.
Carla M PradoDepartment of Agricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, AB, Canada.
Puneeta TandonDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.
Kieran HalloranDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.
Stephanie SmithDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.
Jennifer A McCombeDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.
Bruce RitchieDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.
Edith PituskinCollege of Health Sciences, University of Alberta, Edmonton, AB, Canada.
Mark J HaykowskyCollege of Health Sciences, University of Alberta, Edmonton, AB, Canada.
Richard CouldenDepartment of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada.
Derek EmeryDepartment of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada.
Albert K TsuiDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.
Kai Y WuDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.
Gavin Y OuditDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.
Justin A EzekowitzDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.
Richard B ThompsonDepartment of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Short-term clinical outcomes from SARS-CoV-2 infection are generally favorable. However, 15-20% of patients report persistent symptoms of at least 12 weeks duration, often referred to as long COVID. Population studies have also demonstrated an increased risk of incident diabetes and cardiovascular disease at 12 months following infection. While imaging studies have identified multi-organ injury patterns in patients with recovered COVID-19, their respective contributions to the disability and morbidity of long COVID is unclear. Methods: A multicenter, observational study of 215 vaccine-naïve patients with clinically recovered COVID-19, studied at 3-6 months following infection, and 133 healthy volunteers without prior SARS-CoV-2 infection. Patients with recovered COVID-19 were screened for long COVID related symptoms and their impact on daily living. Multi-organ, multi-parametric magnetic resonance imaging (MRI) and circulating biomarkers were acquired to document sub-clinical organ pathology. All participants underwent pulmonary function, aerobic endurance (6 min walk test), cognition testing and olfaction assessment. Clinical outcomes were collected up to 1 year from infection. The primary objective of this study is to identify associations between organ injury and disability in patients with long-COVID symptoms in comparison to controls. As a secondary objective, imaging and circulating biomarkers with the potential to exacerbate cardiovascular health were characterized. Discussion: Long-term sequelae of COVID-19 are common and can result in significant disability and cardiometabolic disease. The overall goal of this project is to identify novel targets for the treatment of long COVID including mitigating the risk of incident cardiovascular disease. Study registration: clinicaltrials.gov (MOIST late cross-sectional study; NCT04525404).

Indexed as

circulating biomarkersfunctional assessmentlong COVIDMRIrecovered COVID-19

Identifiers

PMID39114821
PMCPMC11303169

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.