ArticleFrontiers in public health2024
Prognosis of patients with prolonged disorders of consciousness after brain injury: a longitudinal cohort study.
Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Effects of single-modality sensory stimulation on brain function in patients with prolonged disorders of consciousness: a near-infrared spectroscopy-based study.Frontiers in neurology · 2026Trial
- Rehabilitation Outcomes in Patients Who Regained Consciousness.Neurology international · 2026Article
- Early Functional Recovery Trajectories After Severe Traumatic Brain Injury: A Secondary Analysis of the TBIMS National Database.Brain sciences · 2026Article
- Parkinsonism associated with prolonged unresponsive wakefulness syndrome after blunt head injury: a clinico-pathological study.Free neuropathology · 2025Article
- The cost of rehabilitation after critical illness: a comparison of hospitalization costs for traumatic brain injury and non-traumatic brain injury patients with disorders of consciousness.Frontiers in public health · 2025Article
- Prognosis and recovery trajectories in prolonged disorders of consciousness: protocol for the PDOCC 5-year prospective cohort study.Frontiers in neurologyArticle
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Authors and funding
5 authors.
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Abstract
Background: The findings regarding the prognosis of prolonged disorders of consciousness (PDOC) vary widely among different studies. This study aims to investigate the mortality, consciousness recovery and disabilities of patients with PDOC after brain injury. Methods: A total of 204 patients with PDOC were included in a longitudinal cohort study, including 129 males and 75 females. There were 112 cases of traumatic brain injury (TBI), 62 cases of cerebral hemorrhage (CH), 13 cases of cerebral infarction (CI) and 17 cases of ischemic hypoxic encephalopathy (IHE). The status of consciousness at 1, 2, 3, 6, 12, 18, 24, 36, 48 months of the disease course was assessed or followed up using the Revised Coma Recovery Scale (CRS-R). If the patients were conscious, the disability Rating Scale (DRS) was also performed. The prognosis of different PDOC including coma, vegetative state (VS) and minimal conscious state (MCS) was analyzed. The survival patients were screened for variables and included in multivariate binary Logistic regression to screen the factors affecting the recovery of consciousness. Results: The mortality rates at 12, 24, 36, and 48 months were 10.7, 23.4, 38.9, and 68.4%, respectively. The median time of death was 18 months (8.75, 29). The probability of MCS regaining consciousness was higher than VS ( Conclusion: The prognosis of MCS is more favorable than VS, with comparable outcomes between MCS- and MCS+, while comatose patients was the poorest. TBI has the best prognosis and IHE has the worst prognosis.
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