Evidence map›Paper›PMID 39114484›Full record

ArticleFrontiers in neuroscience2024

A dual target molecular magnetic resonance imaging probe for noninvasive profiling of pathologic alpha-synuclein and microgliosis in a mouse model of Parkinson's disease.

Xianwei Sun, Andrew Badachhape, Prajwal Bhandari, Jeannie Chin, Ananth Annapragada, Eric Tanifum

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xianwei SunDepartment of Radiology, Baylor College of Medicine, Houston, TX, United States.
Andrew BadachhapeDepartment of Radiology, Baylor College of Medicine, Houston, TX, United States.
Prajwal BhandariDepartment of Radiology, Baylor College of Medicine, Houston, TX, United States.
Jeannie ChinDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, United States.
Ananth AnnapragadaDepartment of Radiology, Baylor College of Medicine, Houston, TX, United States.
Eric TanifumDepartment of Radiology, Baylor College of Medicine, Houston, TX, United States.

Funding

MRI molecular imaging of alpha-synuclein aggregates in a mouse model of Parkinson's diseaseR21AG067131 · NIA · BAYLOR COLLEGE OF MEDICINE · PI TANIFUM, ERIC · 2020 to 2020
$440k
NIA NIH HHS R21 AG067131
6 · The paper itself

Abstract

The pathogenesis of Parkinson's disease (PD) is characterized by progressive deposition of alpha-synuclein (α-syn) aggregates in dopaminergic neurons and neuroinflammation. Noninvasive

Indexed as

accelerated alpha-synuclein clearanceimaging of alpha-synucleinmolecular MRI of microgliosisMRI of alpha-synucleinMRI of neuroinflammation

Identifiers

PMID39114484
PMCPMC11303179

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.