Evidence map›Paper›PMID 39114392›Full record

ArticleIndian journal of nephrology

Effectiveness of Lactoferrin in the Treatment of Anemia in Chronic Kidney Disease: A Single-Center Pilot Study.

Kushal Kekan, Smita Divyaveer, Madhuri Kashyap, Madhumita Premkumar, Deepy Zohmangaihi, Nabhajit Mallik, Deepesh Lad, Akanksha Sharma, Gowri Shankar S, Sahil Garg and 7 more

Abstract read
In one paragraph

Article in Indian journal of nephrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kushal KekanDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Smita DivyaveerDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Madhuri KashyapDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Madhumita PremkumarDepartment of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Deepy ZohmangaihiDepartment of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Nabhajit MallikDepartment of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Deepesh LadDepartment of Clinical Hematology and Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Akanksha SharmaDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Gowri Shankar SDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Sahil GargDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Arun PrabhaharDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Ankur ChaudharyDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Shabna SuleimanDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Imran RatherDepartment of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Manish VermaDepartment of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Ravjit Singh JassalDepartment of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Harbir Singh KohliDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Anemia occurs in majority of patients with chronic kidney disease despite adequate dialysis and iron replete status. This study was done to evaluate the effects of lactoferrin with or without iron supplementation for the treatment of anemia in patients with chronic kidney disease (CKD). Materials and Methods: In this prospective, observational, single-center, single-arm pilot study, adult patients aged >18 years, having stage 5 CKD (estimated glomerular filtration rate [eGFR] <15 ml/min/1.73 m Results: A total of 46 CKD patients having anemia were included. Patients had a mean age of 39.3 years, and a majority were men (69.6%). Improvement in the mean (SD) Hb level (g/dl) was observed from baseline (8.18 [1.19]) to Week 2 (8.54 [1.57]), which attained significance at Week 4 (8.96 [1.93]; Conclusion: Oral lactoferrin therapy was effective in improving hemoglobin levels in patients with advanced CKD and anemia. The effects of lactoferrin therapy on inflammatory markers remain uncertain.

Indexed as

Anemiachronic kidney diseaseCKDhemoglobininflammationironlactoferrin

Identifiers

PMID39114392
PMCPMC11302601

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.