Evidence map›Paper›PMID 39114047›Full record

ArticleHeliyon2024

Boosting physical performance in SD rats through brain-targeted delivery of caffeine-loaded transferrin liposomes.

Hezhang Yun, Wenbo Su, Ting You, Jing Wang, Yuxuan Ying, Can Wang, Yuyi Ren, Bin Lu, Yi Li, Chang Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hezhang YunSchool of Physical Education, Zhejiang Guangsha Vocational and Technical University of Construction, Dongyang, 322100, China.
Wenbo SuDepartment of Sports Teaching and Research, Lanzhou University, Lanzhou, 730000, China.
Ting YouCollege of Recreation and Tourism, Beijing Sport University, Beijing, 100084, China.
Jing WangSchool of Physical Education, Zhejiang Guangsha Vocational and Technical University of Construction, Dongyang, 322100, China.
Yuxuan YingSchool of Physical Education, Zhejiang Guangsha Vocational and Technical University of Construction, Dongyang, 322100, China.
Can WangCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Yuyi RenSchool of Sport Science, Beijing Sport University, Beijing, 100084, China.
Bin LuSchool of Physical Education, Zhejiang Guangsha Vocational and Technical University of Construction, Dongyang, 322100, China.
Yi LiBeijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
Chang LiuSchool of Sport Science, Beijing Sport University, Beijing, 100084, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to explore the impact of caffeine (CAF) encapsulated in transferrin-modified, sterically-stabilized liposomes (Tf-SSL) on the physical performance of rats, specifically forelimb grip strength, running, and swimming. The brain-targeted drug delivery system, Tf-SSL, was used for the administration of caffeine. 168 male Sprague-Dawley (SD) rats were randomly assigned to different groups, including swimming, running, running wheel, and strength groups. Each group was further subdivided into high, medium, and low dose free caffeine (HCAF, MCAF, LCAF) and Tf-SSL CAF groups, along with a control group (CON). The strength, swimming, and running groups underwent training for four weeks, three times per week. The running wheel group was placed in rearing cages for a one-week adaptation period. After the final training session, the resistance, swimming, running, and running wheel exercise capacities of the rats were tested. The rats were administered treatment via tail vein injection, while the blank CON group received 0.9 % saline solution without treatment throughout the entire process. The results demonstrated a Tf-SSL CAF group encapsulation rate of 70.58 ± 5.14 %. Increasing the concentration of supplemented caffeine led to enhanced forelimb grip strength in rats, with significant differences observed in HCAF alone group, medium-dose Tf-SSL CAF (MTf-SSL CAF), and high-dose Tf-SSL CAF (HTf-SSL CAF) groups compared to the CON group. In the running and swimming experiments, higher caffeine supplementation concentrations correlated with increased running and swimming time to exhaustion, and the MTf-SSL CAF group showed longer running and swimming time compared to the HCAF alone group. The results of rat striatal dopamine levels indicated that increased caffeine supplementation concentrations led to higher dopamine secretion, with significantly different striatal concentrations in the HCAF group, MTf-SSL CAF group, and HTf-SSL CAF group compared to the CON group. The running wheel experiment revealed that rats in the medium- and high-dose Tf-SSL CAF groups exhibited greater 6-h running distances than the HCAF group and CON group. In conclusion, caffeine supplementation improved the physical performance of rats, with the high concentration CAF group outperforming the low and medium concentration groups. Furthermore, Tf-SSL CAF demonstrated superior physical enhancement compared to caffeine supplementation alone.

Indexed as

Brain-targeted drug deliveryCaffeineForelimb grip strengthMuscle endurancePhysical performanceTransferrin-modified liposomes

Identifiers

PMID39114047
PMCPMC11305279

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.