ArticleTheranostics2024
Transcranial blood-brain barrier opening in Alzheimer's disease patients using a portable focused ultrasound system with real-time 2-D cavitation mapping.
Abstract readClinical Trial, Phase I
In one paragraph
Article in Theranostics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ultrasound-induced blood-brain barrier opening in Alzheimer's disease: a systematic review of clinical studies.Aging clinical and experimental research · 2026Pooled it
- Focused ultrasound-mediated lipid nanoparticle delivery for brain gene editing.Molecular therapy. Nucleic acids · 2026Article
- Advances in ultrasound-mediated nanozyme systems in therapeutic applications.Ultrasonics sonochemistry · 2026Review
- Low-intensity transcranial ultrasound neuromodulation promotes neuronal regeneration: A new hope for noninvasive treatment of neurodegenerative diseases.Neural regeneration research · 2026Article
- From brain waves to heartbeats: Exploring the combined role of electroencephalography and heart-rate variability in Alzheimer's disease diagnosis and management.Journal of Alzheimer's disease : JAD · 2026Review
- Myostatin Research: From Molecular Understanding to Clinical Translation for Musculoskeletal and Metabolic Disorders.International journal of molecular sciences · 2026Review
- From Polyphenols to Prodrugs: Bridging the Blood-Brain Barrier with Nanomedicine and Neurotherapeutics.International journal of molecular sciences · 2026Review
- Data-Driven Feedback Identifies Focused Ultrasound Exposure Regimens for Improved Nanotheranostic Targeting of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Safe focused ultrasound-mediated blood-brain barrier opening is driven primarily by transient reorganization of tight junctions.Communications engineering · 2026Article
- Development and Implementation of a Radiation Safety Screening Protocol for a Clinical Study Using Amyloid Positron Emission Tomography Imaging.Ochsner journal · 2026Article
- Focused ultrasound-mediated blood-brain barrier modulation is associated with adult hippocampal neurogenic responses linked to zinc-dependent signaling.Theranostics · 2026Article
- Research Progress on the Pathogenesis, Therapeutic Strategies, and Phthalocyanine Compounds for Alzheimer's Disease.Current Alzheimer research · 2026Review
- Ultrasound-responsive micro/nanobubbles based intelligent theranostic systems for precision tumor therapy.Journal of nanobiotechnology · 2025Review
- A review of neuroprotective properties ofAnnals of medicine · 2025Review
- Feasibility of ultrasound-mediated blood-brain barrier opening in sheep using sonolucent cranial implants.Scientific reports · 2025Article
- Acoustic emissions dose and spatial control of blood-brain barrier opening with focused ultrasound.Device · 2025Article
- Focused ultrasound-induced blood-brain barrier opening promotes glioprotective phenotypes in ACSA-II+ murine astrocytes.iScience · 2025Article
- Response of Serum-Isolated Extracellular Vesicles to Focused Ultrasound-Mediated Blood-Brain Barrier Opening.Ultrasound in medicine & biology · 2025Article
- Focused ultrasound-mediated APOE4 knockdown in mouse brain.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability.Journal of nanobiotechnology · 2025Review
Corrections and comments
- Update of
Authors and funding
13 authors.
Sua BaeDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Keyu LiuDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Antonios N PouliopoulosDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Robin JiDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Sergio Jiménez-GambínDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Omid YousefianDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Alina R Kline-SchoderDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Alec J BattsDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Fotios N TsitsosDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Danae KokossisDepartment of Radiation Oncology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Akiva MintzDepartment of Radiology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Lawrence S HonigDepartment of Neurology and Taub Institute, Columbia University Irving Medical Center 10032, New York, NY, USA.
Elisa E KonofagouDepartment of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Funding
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHILIP L DE JAGER · 2020 to 2026
$30.1MAssessment of Ultrsound-facilitated Neurotherapeutics in Alzheimer's DiseaseR01AG038961 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2011 to 2020
$5.1MA theranostic system for ultrasound-facilitated blood-brain barrier openingR01EB029338 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KONOFAGOU, ELISA E. · 2020 to 2023
$2.6MNIA NIH HHS P30 AG066462NIA NIH HHS R01 AG038961NIBIB NIH HHS R01 EB029338
Abstract
PubMed holds no abstract for this paper.
Indexed as
Alzheimer DiseaseBlood-Brain BarrierMagnetic Resonance ImagingMicrobubblesAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersDrug Delivery SystemsFemaleHumansMaleMiddle AgedPilot ProjectsAmyloid beta-PeptidesBiomarkersAlzheimer's diseaseblood-brain barriercavitation mappingfocused ultrasoundmicrobubbles
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.