Evidence map›Paper›PMID 39113706›Full record

ArticleInternational journal of biological sciences2024

siRNA-loaded folic acid-modified TPGS alleviate MASH

Manman Zhu, Yong Cheng, Li Zuo, Bao Bin, Haiyuan Shen, Tao Meng, Zihao Wu, Peng Rao, Yue Tang, Shuojiao Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Manman ZhuDepartment of Pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
Yong ChengSchool of Pharmacy, Anhui Medical University, Hefei 230032, Anhui Province, China.
Li ZuoDepartment of Pathology, Laboratory of Mucosal Barrier Pathobiology, Anhui Medical University, Hefei230032, Anhui, China.
Bao BinBoston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Haiyuan ShenDepartment of Pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
Tao MengDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui Province, China.
Zihao WuDepartment of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
Peng RaoDepartment of Pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
Yue TangDepartment of Pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
Shuojiao LiDepartment of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, Anhui Province, China.
Honghai XuDepartment of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
Guoping SunDepartment of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
Hua WangDepartment of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
Guiyang ZhangDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui Province, China.
Jiatao LiuDepartment of Pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages show high plasticity and play a vital role in the progression of metabolic dysfunction-associated steatohepatitis (MASH). X-box binding protein 1 (XBP1), a key sensor of the unfolded protein response, can modulate macrophage-mediated pro-inflammatory responses in the pathogenesis of MASH. However, how XBP1 influences macrophage plasticity and promotes MASH progression remains unclear. Herein, we formulated an

Indexed as

Folic AcidMacrophagesRNA, Small InterferingX-Box Binding Protein 1AnimalsEndoplasmic Reticulum StressFatty LiverMaleMiceMice, Inbred C57BLNanoparticlesVitamin EFolic AcidRNA, Small InterferingtocophersolanVitamin EX-Box Binding Protein 1Xbp1 protein, mouseD-α-Tocopheryl polyethylene glycol 1000 succinateEndoplasmic reticulum stressMacrophagesMetabolic dysfunction-associated steatohepatitisX-box binding protein 1

Identifiers

PMID39113706
PMCPMC11302883

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.