Evidence map›Paper›PMID 39113483›Full record

ArticleAsian spine journal2024

Outcome of intradiscal condoliase injection therapy for patients with recurrent lumbar disc herniation.

Noritaka Suzuki, Yawara Eguchi, Takashi Hirai, Takuya Takahashi, Yohei Takahashi, Kota Watanabe, Tomohiro Banno, Kyohei Sakaki, Satoshi Maki, Yuuichi Takano and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian spine journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Noritaka SuzukiDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yawara EguchiDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Takashi HiraiDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Takuya TakahashiDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Yohei TakahashiDepartment of Orthopaaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Kota WatanabeDepartment of Orthopaaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Tomohiro BannoDepartment of Orthopaedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Kyohei SakakiDepartment of Orthopaedic Surgery, Saiseikai Kawaguchi General Hospital, Kawaguchi, Japan.
Satoshi MakiDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yuuichi TakanoDepartment of Orthopaedic Surgery, Inanami Spine and Joint Hospital, Tokyo, Japan.
Yuki TaniguchiDepartment of Orthopaedic Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Yasuchika AokiDepartment of Orthopaedic Surgery, Eastern Chiba Medical Center, Togane, Japan.
Takamitsu KonishiDepartment of Orthopaedic Surgery, Tokyo Medical University, Tokyo, Japan.
Yutaka HiraizumiDepartment of Orthopaedic Surgery, Showa University School of Medicine, Tokyo, Japan.
Masatsune YamagataDepartment of Orthopaedic Surgery, Oyumino Central Hospital Mobara Clinic, Mobara, Japan.
Akihiro HirakawaDepartment of Clinical Biostatistics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Seiji OhtoriDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designRetrospective cohort study. PURPOSE: This study aimed to compare data from patients who received intradiscal condoliase (chondroitin sulfate ABC endolyase) injection for primary lumbar disc herniation (LDH) and recurrent LDH. OVERVIEW OF LITERATURE: Chemonucleolysis with condoliase for LDH is a treatment with relatively good results and a high safety profile; however, few studies have reported recurrence after LDH surgery.

methodsThe study participants were 249 patients who underwent intradiscal condoliase injection for LDH at nine participating institutions, including 241 patients with initial LDH (group C) and eight with recurrent LDH (group R). Patient characteristics including age, sex, body mass index, disease duration, intervertebral LDH level, smoking history, and diabetes history were evaluated. Low back pain/leg pain Numerical Rating Scale (NRS) scores and the Oswestry Disability Index (ODI) were used to evaluate clinical symptoms before treatment and at 6 months and 1 year after treatment.

resultsLow back pain NRS scores (before treatment and at 6 months and 1 year after treatment, respectively) in group C (4.9 → 2.6 → 1.8) showed significant improvement until 1 year after treatment. Although a tendency for improvement was observed in group R (3.5 → 2.8 → 2.2), no significant difference was noted. Groups C (6.6 → 2.4 → 1.4) and R (7.0 → 3.1 → 3.2) showed significant improvement in the leg pain NRS scores after treatment. Group C (41.4 → 19.5 → 13.7) demonstrated significant improvement in the ODI up to 1 year after treatment; however, no significant difference was found in group R (35.7 → 31.7 → 26.4).

conclusionsAlthough intradiscal condoliase injection is less effective for LDH recurrence than for initial cases, it is useful for improving leg pain and can be considered a minimally invasive and safe treatment method.

Indexed as

Back painIntervertebral disc chemolysisIntervertebral disc displacementLeg pain

Identifiers

PMID39113483
PMCPMC11366550

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.