Evidence map›Paper›PMID 39113083›Full record

ArticleBMC medicine2024

History of childhood maltreatment associated with hospitalization or death due to COVID-19: a cohort study.

Yue Wang, Fenfen Ge, Thor Aspelund, Helga Ask, Arna Hauksdóttir, Kejia Hu, Jóhanna Jakobsdóttir, Helga Zoega, Qing Shen, Heather C Whalley and 6 more

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In one paragraph

Article in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yue Wang *Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Fenfen Ge *Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Thor AspelundCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Helga AskPsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
Arna HauksdóttirCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Kejia HuInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Jóhanna JakobsdóttirCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Helga ZoegaCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Qing ShenClinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, China.
Heather C WhalleyCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Ole Birger Vesterager PedersenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kelli LehtoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Ole A AndreassenInstitute of Clinical Medicine, NORMENT Centre, University of Oslo, Oslo, Norway.
Fang FangInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Huan SongCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Unnur A ValdimarsdóttirCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland. unnurav@hi.is.ORCID 0000-0001-5382-946X

Funding

China Scholarship Council 202106240012Estonian Research Council No.PSG615Horizon 2020 will providentNordForsk NO. 105668/138929NordForsk NO. 156298Research Council of Norway #223273Research Council of Norway #324499Research Council of Norway #324620
6 · The paper itself

Abstract

backgroundChildhood maltreatment (CM) has been indicated in adverse health outcomes across the lifespan, including severe infection-related outcomes. Yet, data are scarce on the potential role of CM in severe COVID-19-related outcomes as well as on mechanisms underlying this association.

methodsWe included 151,427 individuals in the UK Biobank who responded to questions on the history of CM in 2016 and 2017 and were alive on January 31, 2020. Binomial logistic regression models were performed to estimate the association between a history of CM and severe COVID-19 outcomes (i.e. hospitalization or death due to COVID-19), as well as COVID-19 diagnosis and vaccination as secondary outcomes. We then explored the potential mediating roles of socio-economic status, lifestyle and pre-pandemic comorbidities, and the effect modification by polygenic risk score for severe COVID-19 outcomes.

resultsThe mean age of the study population at the start of the pandemic was 67.7 (SD = 7.72) years, and 56.5% were female. We found the number of CM types was associated with the risk of severe COVID-19 outcomes in a graded manner (p

conclusionsOur results add to the growing knowledge base indicating the role of childhood maltreatment in negative health outcomes across the lifespan, including severe COVID-19-related outcomes. The identified factors underlying this association represent potential intervention targets for mitigating the harmful effects of childhood maltreatment in COVID-19 and similar future pandemics.

Indexed as

COVID-19HospitalizationAgedChildChild AbuseCohort StudiesFemaleHumansMaleMiddle AgedRisk FactorsSARS-CoV-2United KingdomChildhood maltreatmentCOVID-19HospitalizationMortalityPsychiatric disorders

Identifiers

PMID39113083
PMCPMC11304908

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.