Evidence map›Paper›PMID 39112969›Full record

ArticleBMC cancer2024

AP-2α gene deregulation is associated with renal cell carcinoma patient survival.

Po-Hung Lin, Chin-Hsuan Hsieh, Kai-Jie Yu, I-Hung Shao, Cheng-Keng Chuang, Todd Hsu, Wen-Hui Weng, See-Tong Pang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Po-Hung Lin *Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, LinKou Branch. No. 5, Fushing St, Taoyuan, 333, Taiwan.
Chin-Hsuan Hsieh *Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, LinKou Branch. No. 5, Fushing St, Taoyuan, 333, Taiwan.
Kai-Jie YuDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital, LinKou Branch. No. 5, Fushing St, Taoyuan, 333, Taiwan.
I-Hung ShaoDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital, LinKou Branch. No. 5, Fushing St, Taoyuan, 333, Taiwan.
Cheng-Keng ChuangDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital, LinKou Branch. No. 5, Fushing St, Taoyuan, 333, Taiwan.
Todd HsuInstitute of Bioscience and Biotechnology, Center of Excellence for Marine Bioenvironment and Biotechnology, National Taiwan Ocean University, Keelung, 202, Taiwan.
Wen-Hui WengDepartment of Chemical Engineering and Biotechnology, Graduate Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, Taipei, 106, Taiwan.
See-Tong PangDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital, LinKou Branch. No. 5, Fushing St, Taoyuan, 333, Taiwan. jacobpang@cgmh.org.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRenal cell carcinoma (RCC), one of the most fatal urologic tumors, accounts for approximately 3% of all adult cancers and exhibits a high metastatic index at diagnosis and a high rate of relapse. Radical or partial nephrectomy is a curative option for nonmetastatic RCCs. Targeted therapy has been shown to improve the survival of patients with metastatic RCCs. However, the underlying cellular and molecular events associated with RCC pathogenesis are not well known.

methodsTo investigate the clinical role of the transcription factor activator protein (AP)-2α in RCC, methylated CpG island recovery assays and microarray analysis were employed. COBRA and RT‒qPCR assays were performed to assess AP-2α expression in RCC.

resultsA negative correlation was noted between AP-2α mRNA expression levels and methylation status. Multivariate analyses showed that AP-2α mRNA was a major risk factor not only for overall and disease-free survival in RCC but also for disease-free survival in clear cell RCC.

conclusionsOur results indicated that AP-2α expression was deregulated in RCC and associated with overall patient survival and disease-free survival. Such findings suggest that AP-2α might play an important role in the pathogenesis of RCC.

Indexed as

Carcinoma, Renal CellDNA MethylationGene Expression Regulation, NeoplasticKidney NeoplasmsTranscription Factor AP-2AdultAgedCpG IslandsDisease-Free SurvivalFemaleHumansMaleMiddle AgedPrognosisRNA, MessengerRNA, MessengerTranscription Factor AP-2AP-2αOverall survivalPrognostic factorRenal cell carcinomaTFAP2A

Identifiers

PMID39112969
PMCPMC11304775

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.