ArticleBMC emergency medicine2024
Blood pressure variability and prognostic significance in traumatic brain injury: analysis of the eICU-CRD database.
Article in BMC emergency medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Prognostic utility of on-admission pulse pressure in hospitalized patients with traumatic brain injury.World journal of critical care medicine · 2026Article
- Blood Pressure Variability and Acute Kidney Injury in Traumatic Intracranial Hemorrhage : A Retrospective Cohort Study Using the MIMIC-IV Database.Journal of Korean Neurosurgical Society · 2026Article
- Blood pressure variability and blood pressure rhythm phenotypes in children with severe encephalitis complicated by paroxysmal sympathetic hyperactivity.Frontiers in pharmacology · 2026Article
- Impact of Prehospital Blood Pressure Profile on Functional Outcome After Traumatic Brain Injury.Journal of clinical medicine · 2025Article
- Assessment value of blood pressure variability combined with serum tau protein for the prognosis of patients with traumatic brain injury.Frontiers in neurologyArticle
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Authors and funding
5 authors.
Funding
Abstract
backgroundPreliminary evidence demonstrates that visit-to-visit systolic blood pressure (SBP) variability is a prognostic factor of TBI. However, literature regarding the impact of initial blood pressure management on the outcomes of TBI patients is limited. We aimed to further validate the clinical significance of BPV on the prognostic outcomes of patients with TBI.
methodsWe performed the analysis by using individual patient-level data acquired from the eICU-CRD, which collected 200,859 ICU admissions of 139,367 patients in 2014 and 2015 from 208 US hospitals. Adult patients with traumatic intraparenchymal hemorrhage or contusion were included. The primary outcome was in-hospital mortality and the secondary outcome was discharge-home rate. Blood pressure variability (BPV) was calculated according to standard criteria: at least six measurements were taken in the first 24 h (hyperacute group) and 36 over days 2-7 (acute group). We estimated the associations between BPV and outcomes with logistic and proportional odds regression models. The key parameter for BPV was standard deviation (SD) of SBP, categorized into quintiles. We also calculated the average real variability (ARV), as well as maximum, minimum, and mean SBP for comparison in our analysis.
resultsWe studied 1486 patients in the hyperacute group and 857 in the acute group. SD of SBP had a significant association with the in-hospital mortality for both the hyperacute group (highest quintile adjusted OR 2.28 95% CI 1.18-4.42; p
conclusionSystolic BPV seems to predict a poor outcome in patients with TBI. The benefits of early treatment to maintain appropriate SBP level might be enhanced by smooth and sustained control.
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