Evidence map›Paper›PMID 39112892›Full record

Trial reportJournal of neurology2024

Enriched music-supported therapy for individuals with chronic stroke: a randomized controlled trial.

Emma Segura, Jennifer Grau-Sánchez, Xim Cerda-Company, María F Porto, Myriam De la Cruz-Puebla, David Sanchez-Pinsach, Jesus Cerquides, Esther Duarte, Anna Palumbo, Alan Turry and 5 more

Registry-linked trialAbstract readRandomized Controlled TrialPragmatic Clinical Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04507542 (Playing and Singing for the Recovering Brain), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04507542 naunknown statusnot on this map

Playing and Singing for the Recovering Brain: Efficacy of Enriched Social-Motivational Musical Interventions in Stroke Rehabilitation

TypeinterventionalSponsorUniversity of BarcelonaRan2020 to 2022Enrolled60ConditionsStrokeArmsEnriched Music-Supported Therapy, Graded Repetitive Arm Supplementary Program
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Emma SeguraCognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute, 08907, L'Hospitalet de Llobregat, Barcelona, Spain.ORCID http://orcid.org/0000-0002-0797-3011
Jennifer Grau-SánchezCognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute, 08907, L'Hospitalet de Llobregat, Barcelona, Spain. jennifergrau@euit.fdsll.cat.
Xim Cerda-CompanyCognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute, 08907, L'Hospitalet de Llobregat, Barcelona, Spain.
María F PortoCognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute, 08907, L'Hospitalet de Llobregat, Barcelona, Spain.
Myriam De la Cruz-PueblaCognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute, 08907, L'Hospitalet de Llobregat, Barcelona, Spain.
David Sanchez-PinsachArtificial Intelligence Research Institute, Spanish National Research Council, 08193, Bellaterra, Barcelona, Spain.
Jesus CerquidesArtificial Intelligence Research Institute, Spanish National Research Council, 08193, Bellaterra, Barcelona, Spain.
Esther DuarteDepartment of Physical and Rehabilitation Medicine, Hospital del Mar, 08003, Barcelona, Spain.
Anna PalumboRehabilitation Science Program, New York University, 10012, New York, USA.
Alan TurryNordoff-Robbins Center for Music Therapy, New York University, 10012, New York, USA.
Preeti RaghavanDepartment of Physical Medicine and Rehabilitation, John Hopkins University, 21287, Baltimore, MD, USA.
Teppo SärkämöCognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine and Centre of Excellence in Music, Mind, Body and Brain, University of Helsinki, 00100, Helsinki, Finland.
Thomas F MünteDepartment of Neurology, University of Lübeck, 23562, Lübeck, Germany.
Josep Lluis ArcosArtificial Intelligence Research Institute, Spanish National Research Council, 08193, Bellaterra, Barcelona, Spain.
Antoni Rodríguez-FornellsCognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute, 08907, L'Hospitalet de Llobregat, Barcelona, Spain. antoni.rodriguez@icrea.cat.

Funding

Fundació la Marató de TV3 201729.30
6 · The paper itself

Abstract

objectiveMany stroke survivors still present with upper-limb paresis six months post-stroke, impacting their autonomy and quality of life (QoL). We designed an enriched Music-supported Therapy (eMST) program to reduce disability in this population. We evaluated the eMST's effectiveness in improving functional abilities and QoL in chronic stroke individuals compared to the conventional motor program Graded Repetitive Arm Supplementary Program (GRASP).

methodsWe conducted a pragmatic two-arm parallel-group randomized controlled trial with a 3-month follow-up and masked assessment. The eMST involved playing instruments during individual self-administered and group music therapy sessions. The GRASP consisted of self-administered motor exercises using daily objects. Both interventions were completed at home with telemonitoring and involved four one-hour weekly sessions for 10 weeks. The primary outcome was upper-limb motor function measured with the Action Research Arm Test. Secondary outcomes included motor impairment, daily life motor performance, cognitive functions, emotional well-being, QoL, self-regulation, and self-efficacy. Intention-to-treat (ITT) and per-protocol (PP) analyses were conducted including participants who discontinued the intervention and those who completed it entirely, respectively.

resultsFifty-eight chronic stroke patients were randomized to the eMST-group (n = 26; age: 64.2 ± 12.5; 6 [23.1%] females; 2.8 ± 2.9 years post-stroke), and the control group (n = 32; age: 62.2 ± 12; 8 [25%] females; 1.8 ± 6.2 years post-stroke). The eMST-group had more participants achieving a clinically relevant improvement in motor impairment post-intervention than the control group for the ITT (55% vs 21.6%; OR = 4.5 (95% CI 1.4-14); p = .019) and PP analyses (60% vs 20%; OR = 6 (95% CI 1.5-24.7); p = .024), sustained at follow-up. The eMST-group reported greater improvements in emotion (difference = 11.1 (95% CI 0.8-21.5; p = 0.36) and participation (difference = 10.3 (95% CI 0.6-25.9); p = 0.41) subscales of QoL, and higher enjoyment during the sessions (difference = 1 (95% CI 0.3-1.5); p = 0.12). No changes were found in other outcomes.

conclusioneMST demonstrated superiority over conventional motor rehabilitation program in enhancing upper-limb functions and QoL in chronic stroke individuals.

trial registrationClinicalTrials.gov (ID: NCT04507542).

Indexed as

Music TherapyQuality of LifeStrokeStroke RehabilitationAgedChronic DiseaseFemaleFollow-Up StudiesHumansMaleMiddle AgedOutcome Assessment, Health CareTreatment OutcomeUpper ExtremityChronic strokeMotor rehabilitationMusic-based interventionQuality of life

Identifiers

PMID39112892

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.