Evidence map›Paper›PMID 39112813›Full record

ArticleMagma (New York, N.Y.)2024

DCE-Qnet: deep network quantification of dynamic contrast enhanced (DCE) MRI.

Ouri Cohen, Soudabeh Kargar, Sungmin Woo, Alberto Vargas, Ricardo Otazo

Abstract read
In one paragraph

Article in Magma (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Ouri Cohen *Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, 320 East 61st St 10025, USA. coheno1@mskcc.org.ORCID http://orcid.org/0000-0003-3632-8094
Soudabeh Kargar *Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, 320 East 61st St 10025, USA.
Sungmin WooDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alberto VargasDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ricardo OtazoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, 320 East 61st St 10025, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Development of a Clinical CEST MR Fingerprinting Method for Treatment Response Assessment in Brain MetastasesR37CA262662 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Ouri Cohen · 2022 to 2026
$3.4M
Rapid motion-robust quantitative DCE-MRI for the assessment of gynecologic cancersR01CA244532 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI AKIN, OGUZ, OTAZO, RICARDO · 2020 to 2024
$2.9M
NCI NIH HHS P30 CA008748NCI NIH HHS P30-CA008748NCI NIH HHS R01 CA244532NCI NIH HHS R01-CA244532NCI NIH HHS R37 CA262662NCI NIH HHS R37-CA262662
6 · The paper itself

Abstract

introductionQuantification of dynamic contrast-enhanced (DCE)-MRI has the potential to provide valuable clinical information, but robust pharmacokinetic modeling remains a challenge for clinical adoption.

methodsA 7-layer neural network called DCE-Qnet was trained on simulated DCE-MRI signals derived from the Extended Tofts model with the Parker arterial input function. Network training incorporated B

resultsThe DCE-Qnet reconstruction outperformed NLSQ in the phantom. The coefficient of variation (CV) in the healthy cervix varied between 5 and 51% depending on the parameter. Parameter values in the tumor agreed with previous studies despite differences in methodology. The CV in the tumor varied between 1 and 47%.

conclusionThe proposed approach provides comprehensive DCE-MRI quantification from a single acquisition. DCE-Qnet eliminates the need for separate T

Indexed as

Contrast MediaImage Processing, Computer-AssistedMagnetic Resonance ImagingNeural Networks, ComputerPhantoms, ImagingUterine Cervical NeoplasmsAdultAlgorithmsCervix UteriDeep LearningFemaleHealthy VolunteersHumansImage EnhancementLeast-Squares AnalysisReproducibility of ResultsContrast MediaDCEDeep learningDRONENeural network

Identifiers

PMID39112813
PMCPMC11996236

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.