Evidence map›Paper›PMID 39112742›Full record

SynthesisBreast cancer research and treatment2024

Barrier films or dressings for the prevention of acute radiation dermatitis in breast cancer: a systematic review and network meta-analysis.

Henry C Y Wong, Shing Fung Lee, Saverio Caini, Adrian Wai Chan, Jennifer Y Y Kwan, Mark Waddle, Stephen Sonis, Patries Herst, Sara Alcorn, Pierluigi Bonomo and 16 more

Registry-linked trialAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Breast cancer research and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07357506 (Mitigating Cutaneous Toxicity in Patients Undergoing TomoTherapy; A Randomized Controlled Trial of Skin-Protective Strategies), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07357506 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Mitigating Cutaneous Toxicity in Patients Undergoing TomoTherapy; A Randomized Controlled Trial of Skin-Protective Strategies

TypeinterventionalSponsorKing Faisal Specialist Hospital & Research CenterRan2026 to 2028Enrolled104ConditionsHead and Neck CancerArmsFragrance-Free Emollient (Glycerol-Based), A fragrance-free, glycerol-based emollient applied to the skin from day 1 of TomoTherapy., Mepitel Film (Silicone-Based Semi-Permeable Barrier Film)
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. MASCC oncodermatology clinical practice statement: prevention and management of acute radiation dermatitis with Mepitel Film and Hydrofilm.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Guideline
  3. MASCC oncodermatology clinical practice statement: prevention of acute radiation dermatitis using barrier-forming topical agents.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Henry C Y WongDepartment of Oncology, Princess Margaret Hospital, Kowloon West Cluster, Hospital Authority, Hong Kong S.A.R., China. henrywong3011@gmail.com.
Shing Fung LeeDepartment of Radiation Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore.
Saverio CainiCancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention, and Clinical Network (ISPRO), Florence, Italy.
Adrian Wai ChanDepartment of Clinical Oncology, Tuen Mun Hospital, New Territories West Cluster, Hospital Authority, Kowloon, Hong Kong S.A.R., China.
Jennifer Y Y KwanRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada.
Mark WaddleDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
Stephen SonisDivision of Oral Medicine, Brigham and Women's Hospital and the Dana-Farber Cancer Institute, Boston, MA, USA.
Patries HerstDepartment of Radiation Therapy, University of Otago, Wellington, New Zealand.
Sara AlcornDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN, USA.
Pierluigi BonomoDepartment of Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy.
Cindy WongUnion Oncology Centre, Kowloon, Hong Kong S.A.R., China.
Kimberly CorbinDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
J Isabelle ChoiNew York Proton Center, New York, NY, USA.
Agata RembielakClinical Oncology Department, The Christie NHS Foundation Trust, Manchester, UK.
Muna AlKhaifiDepartment of Family and Community Medicine, University of Toronto, Toronto, ON, Canada.
Gustavo Nader MartaDepartment of Radiation Oncology, Hospital Sírio-Libanês, São Paulo, Brazil.
Dirk RadesDepartment of Radiation Oncology, University of Lübeck, Luebeck, Germany.
Corina van den HurkNetherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.
Julie Ryan WolfDepartment of Dermatology, University of Rochester Medical Centre, Rochester, NY, USA.
Raymond J ChanCaring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, Australia.
Leonard Christopher SchmeelDepartment of Radiation Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Michael LockLondon Regional Cancer Program, London Health Sciences Centre, Schulich School of Medicine & Dentistry, London, ON, Canada.
Tarek HijalDepartment of Oncology, McGill University, Montreal, QC, Canada.
Jeffrey CaoDepartment of Oncology, Division of Radiation Oncology, University of Calgary, Calgary, AB, Canada.
Hayeon KimDepartment of Radiation Oncology, Magee Womens Hospital, University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA, USA.
Edward ChowDepartment of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBarrier films or dressings were reported to be effective in preventing radiation dermatitis (RD) in breast cancer patients, but their comparative efficacy is unknown.

methodsA systematic literature search was performed on Embase, MEDLINE and Cochrane CENTRAL Registry of Clinical Trials from inception to October 20, 2023. Randomised controlled trials (RCTs) comparing barrier films or dressings to the standard of care (SOC) or other interventions were included. We estimated summary odds ratios and mean differences using network meta-analysis with random effects. This study was registered with PROSPERO (ID: CRD42023475021).

resultsFourteen RCTs met inclusion criteria. Six interventions were analysed: 3M™ Moisturizing Double Barrier Cream (MDBC), 3M™ No Sting Barrier Film (BF), Hydrofilm® (HF), Mepitel® Film (MF), Silver Leaf Nylon Dressing and StrataXRT®. HF, MF and StrataXRT® reduced the incidence of moist desquamation compared to SOC (HF: OR = 0.08; p = 0.02; MF: OR = 0.31 p < 0.01; StrataXRT®: OR = 0.22, p = 0.04). The ranking of agents from most to least effective in preventing moist desquamation according to P-scores was HF (92.5%), MF (78.5%), StrataXRT® (70.1%), BF (46.4%), Silver Leaf Nylon Dressing (24.9%), MDBC (22.9%) and SOC (14.7%). Only four RCTs on HF and MF included patient-reported outcome (PRO) assessments that allowed pooling for analysis. HF and MF were more effective in reducing pain, itchiness and burning sensation compared to SOC (p < 0.01 for all symptoms).

conclusionHF and MF were effective in preventing RD in breast cancer. Future RCTs should compare these interventions to effective cream preparations, such as topical corticosteroids.

Indexed as

BandagesBreast NeoplasmsRadiodermatitisFemaleHumansRandomized Controlled Trials as TopicTreatment OutcomeBarrier dressingsBarrier filmBreast cancerQuality of lifeRadiation dermatitis

Identifiers

PMID39112742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.