Evidence map›Paper›PMID 39112738›Full record

ArticleNature materials2024

A drug-mediated organic electrochemical transistor for robustly reusable biosensors.

Ziling Jiang, Dekai Ye, Lanyi Xiang, Zihan He, Xiaojuan Dai, Junfang Yang, Qi Xiong, Yingqiao Ma, Danfeng Zhi, Ye Zou and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  5. Article
  6. Review
  7. Article
  8. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ziling JiangSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, China.
Dekai YeBeijing National Laboratory for Molecular Sciences, CAS Kay Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-2487-0698
Lanyi XiangSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, China.
Zihan HeBeijing National Laboratory for Molecular Sciences, CAS Kay Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.
Xiaojuan DaiBeijing National Laboratory for Molecular Sciences, CAS Kay Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.
Junfang YangSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, China.
Qi XiongDepartment of Oncology, Chinese PLA General Hospital, Beijing, China.
Yingqiao MaBeijing National Laboratory for Molecular Sciences, CAS Kay Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0001-8664-981X
Danfeng ZhiSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, China.
Ye ZouBeijing National Laboratory for Molecular Sciences, CAS Kay Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-7642-0226
Qian PengSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, China.
Shu WangBeijing National Laboratory for Molecular Sciences, CAS Kay Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0001-8781-2535
Jia LiDepartment of Orthopedics, Chinese PLA General Hospital, Beijing, China. lijia@301hospital.com.cn.ORCID 0000-0003-1220-2147
Fengjiao ZhangSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, China. fjiaozhang@ucas.ac.cn.ORCID 0000-0001-5088-1780
Chong-An DiSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, China. dicha@iccas.ac.cn.ORCID 0000-0002-6183-1321

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22021002National Natural Science Foundation of China (National Science Foundation of China) 22125504, 61971396, 22021002
6 · The paper itself

Abstract

Reusable point-of-care biosensors offer a cost-effective solution for serial biomarker monitoring, addressing the critical demand for tumour treatments and recurrence diagnosis. However, their realization has been limited by the contradictory requirements of robust reusability and high sensing capability to multiple interactions among transducer surface, sensing probes and target analytes. Here we propose a drug-mediated organic electrochemical transistor as a robust, reusable epidermal growth factor receptor sensor with striking sensitivity and selectivity. By electrostatically adsorbing protonated gefitinib onto poly(3,4-ethylenedioxythiophene):polystyrene sulfonate and leveraging its strong binding to the epidermal growth factor receptor target, the device operates with a unique refresh-in-sensing mechanism. It not only yields an ultralow limit-of-detection concentration down to 5.74 fg ml

Indexed as

Biosensing TechniquesPolystyrenesTransistors, ElectronicBridged Bicyclo Compounds, HeterocyclicElectrochemical TechniquesErbB ReceptorsHumansPolymersBridged Bicyclo Compounds, HeterocyclicErbB Receptorspoly(3,4-ethylene dioxythiophene)PolymersPolystyrenespolystyrene sulfonic acid

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.