Evidence map›Paper›PMID 39112733›Full record

ReviewNature reviews. Urology2024

Neoadjuvant lutetium PSMA, the TIME and immune response in high-risk localized prostate cancer.

Renu S Eapen, Scott G Williams, Sean Macdonald, Simon P Keam, Nathan Lawrentschuk, Lewis Au, Michael S Hofman, Declan G Murphy, Paul J Neeson

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. The role of PSMA-based radioligand therapy in hormone-sensitive prostate cancer.European journal of nuclear medicine and molecular imaging · 2025
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Renu S EapenCancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Australia. Renu.Eapen@petermac.org.ORCID 0000-0003-0590-6234
Scott G WilliamsCancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Australia.
Sean MacdonaldCancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Australia.
Simon P KeamThe Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
Nathan LawrentschukThe Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
Lewis AuCancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Australia.
Michael S HofmanThe Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.ORCID 0000-0001-8622-159X
Declan G Murphy *The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.ORCID 0000-0002-7500-5899
Paul J Neeson *Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Australia. paul.neeson@petermac.org.ORCID 0000-0002-2729-5887

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-risk localized prostate cancer remains a lethal disease with high rates of recurrence, metastases and death, despite attempts at curative local treatment including surgery. Disease recurrence is thought to be a result of failure of local control and occult micrometastases. Neoadjuvant strategies before surgery have been effective in many cancers, but, to date, none has worked in this setting for prostate cancer. Prostate-specific membrane antigen (PSMA)-based theranostics is an exciting and rapidly evolving field in prostate cancer. The novel intravenous radionuclide therapy, [

Indexed as

LutetiumNeoadjuvant TherapyProstatic NeoplasmsAntigens, SurfaceDipeptidesGlutamate Carboxypeptidase IIHeterocyclic Compounds, 1-RingHumansMaleProstate-Specific AntigenRadioisotopesRadiopharmaceuticalsAntigens, SurfaceDipeptidesFOLH1 protein, humanGlutamate Carboxypeptidase IIHeterocyclic Compounds, 1-RingLutetiumProstate-Specific AntigenPSMA-617RadioisotopesRadiopharmaceuticals

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.