Evidence map›Paper›PMID 39112729›Full record

ArticleBiomechanics and modeling in mechanobiology2024

Tensile properties of glaucomatous human sclera, optic nerve, and optic nerve sheath.

Joseph Park, Immi Lee, Somaye Jafari, Joseph L Demer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomechanics and modeling in mechanobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Optic Disc and Retinal Strain Due to Vertical Duction.Investigative ophthalmology & visual science · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joseph ParkDepartment of Ophthalmology and Stein Eye Institute, University of California, Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095-7002, USA.ORCID http://orcid.org/0000-0002-0239-3202
Immi LeeDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Somaye JafariDepartment of Ophthalmology and Stein Eye Institute, University of California, Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095-7002, USA.ORCID http://orcid.org/0000-0001-9822-8545
Joseph L DemerDepartment of Ophthalmology and Stein Eye Institute, University of California, Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095-7002, USA. jld@jsei.ucla.edu.ORCID http://orcid.org/0000-0001-9662-5352

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gregory Darin Field, DAVID S WILLIAMS · 1985 to 2026
$16.8M
BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERYR01EY008313 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOSEPH Louis DEMER · 1991 to 2026
$15.0M
SEARCH FOR NEW GENES IN FAMILIES WITH EPISODIC VERTIGO AND ATAXIAP50DC005224 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BALOH, ROBERT WILLIAM · 2002 to 2006
$7.5M
NEI NIH HHS EY008313NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY008313NIDCD NIH HHS P50 DC005224
6 · The paper itself

Abstract

We characterized the tensile behavior of sclera, optic nerve (ON), and ON sheath in eyes from donors with glaucoma, for comparison with published data without glaucoma. Twelve freshly harvested eyes were obtained from donors with history of glaucoma, of average age 86 ± 7 (standard deviation) years. Rectangular samples were taken from anterior, equatorial, posterior, and peripapillary sclera, and ON sheath, while ON was in native form and measured using calipers. Under physiological temperature and humidity, tissues were preconditioned at 5% strain before loading at 0.1 mm/s. Force-displacement data were converted into engineering stress-strain curves fit by reduced polynomial hyperelastic models and analyzed by tangent moduli at 3% and 7% strain. Data were compared with an age-matched sample of 7 published control eyes. Optic atrophy was supported by significant reduction in ON cross section to 73% of normal in glaucomatous eyes. Glaucomatous was significantly stiffer than control in equatorial and peripapillary regions (P < 0.001). However, glaucomatous ON and sheath were significantly less stiff than control, particularly at low strain (P < 0.001). Hyperelastic models were well fit to stress-strain data (R

Indexed as

GlaucomaOptic NerveScleraStress, MechanicalTensile StrengthAgedAged, 80 and overBiomechanical PhenomenaFemaleHumansMaleGlaucomaOptic nerveOptic nerve sheathScleraTensile

Identifiers

PMID39112729
PMCPMC11554696

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.