Evidence map›Paper›PMID 39112712›Full record

ArticleNature2024

PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity.

Wei Wei, Xuchao Lyu, Andrew L Markhard, Sipei Fu, Rachel E Mardjuki, Peter E Cavanagh, Xianfeng Zeng, Jakub Rajniak, Nannan Lu, Shuke Xiao and 16 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Wei WeiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-8110-0705
Xuchao LyuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1967-3902
Andrew L MarkhardDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Sipei FuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Rachel E MardjukiSarafan ChEM-H, Stanford University, Stanford, CA, USA.
Peter E CavanaghDepartment of Biochemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3146-664X
Xianfeng ZengSarafan ChEM-H, Stanford University, Stanford, CA, USA.
Jakub RajniakSarafan ChEM-H, Stanford University, Stanford, CA, USA.
Nannan LuDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Shuke XiaoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-2103-128X
Meng ZhaoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-5415-8335
Maria Dolores Moya-GarzonDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Steven D TruongDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9624-4461
Jonathan Chiu-Chun ChouDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Lianna W WatDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-6998-0594
Saranya Chidambaranathan-ReghupatyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Laetitia CoassoloDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Duo XuSarafan ChEM-H, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0483-8719
Fangfang ShenSarafan ChEM-H, Stanford University, Stanford, CA, USA.
Wentao HuangDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Cuauhtemoc B RamirezDepartment of Biological Chemistry, University of California Irvine, Irvine, CA, USA.
Cholsoon JangDepartment of Biological Chemistry, University of California Irvine, Irvine, CA, USA.ORCID 0000-0001-6651-4213
Lingyin LiSarafan ChEM-H, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4386-7926
Katrin J SvenssonDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5376-5128
Michael A FischbachSarafan ChEM-H, Stanford University, Stanford, CA, USA.
Jonathan Z LongDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA. jzlong@stanford.edu.ORCID 0000-0003-2631-7463

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
Mechanisms controlling fructose uptake and utilizationR01DK125260 · NIDDK · STANFORD UNIVERSITY · PI Katrin Jennifer Svensson · 2020 to 2026
$3.5M
Chemical control of energy metabolism by N-acyl amino acidsR01DK124265 · NIDDK · STANFORD UNIVERSITY · PI LONG, JONATHAN Z · 2020 to 2024
$2.0M
The role of circulating Slit2 in adipose thermogenesis and diabetesR00DK111916 · NIDDK · STANFORD UNIVERSITY · PI SVENSSON, KATRIN JENNIFER · 2018 to 2020
$731k
CIRCULATING FACTORS THAT REGULATE BROWN AND BEIGE FATR00DK105203 · NIDDK · STANFORD UNIVERSITY · PI LONG, JONATHAN Z · 2018 to 2020
$728k
Investigating Isthmin as an adipose-to-muscle messenger that promotes muscle protein synthesisK99AR081618 · NIAMS · STANFORD UNIVERSITY · PI ZHAO, MENG · 2023 to 2024
$182k
Circulating Factors that Regulate Brown and Beige FatK99DK105203 · NIDDK · DANA-FARBER CANCER INST · PI LONG, JONATHAN Z · 2015 to 2016
$182k
The role of circulating Slit2 in adipose thermogenesis and diabetesK99DK111916 · NIDDK · DANA-FARBER CANCER INST · PI SVENSSON, KATRIN JENNIFER · 2016 to 2017
$180k
American Heart Association-American Stroke Association 24POST1196199NCI NIH HHS T32 CA009054NIAMS NIH HHS K99 AR081618NIDDK NIH HHS K99 DK105203NIDDK NIH HHS K99 DK111916NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R00 DK105203NIDDK NIH HHS R00 DK111916NIDDK NIH HHS R01 DK124265NIDDK NIH HHS R01 DK125260
6 · The paper itself

Abstract

Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans

Indexed as

Body WeightEatingHydrolasesObesityTaurineAcetic AcidAnimalsBody Mass IndexBrain StemCarrier ProteinsEnergy MetabolismExerciseFemaleGlial Cell Line-Derived Neurotrophic Factor ReceptorsGlucoseHomeostasisAcetic AcidacetyltaurineCarrier ProteinsGFRAL protein, mouseGlial Cell Line-Derived Neurotrophic Factor ReceptorsGlucoseHydrolasesPTER protein, humanTaurine

Identifiers

PMID39112712
PMCPMC11374699

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.