Evidence map›Paper›PMID 39112696›Full record

ArticleNature2024

Molecular mimicry in multisystem inflammatory syndrome in children.

Aaron Bodansky, Robert C Mettelman, Joseph J Sabatino, Sara E Vazquez, Janet Chou, Tanya Novak, Kristin L Moffitt, Haleigh S Miller, Andrew F Kung, Elze Rackaityte and 22 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
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  6. Article
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  11. Review
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  14. T-cell and autoantibody profiling for primary immune regulatory disorders.The Journal of allergy and clinical immunology · 2025
    Article
  15. Review
  16. Review
  17. Review
  18. Neuroimmune pathophysiology of long COVID.Psychiatry and clinical neurosciences · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Aaron Bodansky *Department of Pediatrics, Division of Critical Care, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8943-8233
Robert C Mettelman *Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-3527-5616
Joseph J SabatinoWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Sara E VazquezDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Janet ChouDivision of Immunology, Department of Pediatrics, Boston, MA, USA.
Tanya NovakDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-7115-7545
Kristin L MoffittDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
Haleigh S MillerDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Andrew F KungDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Elze RackaityteDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3889-8082
Colin R ZamecnikWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-9477-1388
Jayant V RajanDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Hannah KortbawiDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Caleigh Mandel-BrehmDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Anthea MitchellChan Zuckerberg Biohub SF, San Francisco, CA, USA.
Chung-Yu WangChan Zuckerberg Biohub SF, San Francisco, CA, USA.
Aditi SaxenaChan Zuckerberg Biohub SF, San Francisco, CA, USA.
Kelsey ZornDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-1227-2137
David J L YuDiabetes Center, School of Medicine, University of California San Francisco, San Francisco, CA, USA.
Mikhail V PogorelyyDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
Walid AwadDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
Allison M KirkDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-4286-3678
James AsakiBiomedical Sciences Program, University of California San Francisco, San Francisco, CA, USA.
John V PluvinageDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-9607-2783
Michael R WilsonWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-8705-5084
Laura D ZambranoCOVID-19 Response Team and Coronavirus and Other Respiratory Viruses Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Angela P CampbellCOVID-19 Response Team and Coronavirus and Other Respiratory Viruses Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-2576-482X
Overcoming COVID-19 Network Investigators
Paul G ThomasDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-7955-0256
Adrienne G RandolphDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
Mark S AndersonDiabetes Center, School of Medicine, University of California San Francisco, San Francisco, CA, USA. mark.anderson@ucsf.edu.ORCID 0000-0002-3093-4758
Joseph L DeRisiDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA. joe@derisilab.ucsf.edu.ORCID 0000-0002-4611-9205

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00016 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI WEBBY, RICHARD · 2021 to 2025
$91.4M
Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
Household Respiratory Virus SARS-CoV-2 Transmission and Immunity Sub-Study (HRTS)U01AI144616 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GORDON, AUBREE L, THOMAS, PAUL G. · 2019 to 2025
$43.7M
PanCorVac (Center for Pan-Coronavirus Vaccine Development)P01AI165077 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KAWAOKA, YOSHIHIRO · 2021 to 2023
$11.6M
DECODING THE INTERACTIONS BETWEEN T CELL RECEPTORS AND PEPTIDE-MHCR01AI136514 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Paul G. Thomas · 2018 to 2026
$6.9M
Immunobiology of Influenza Virus-related Critical Illness in Young HostsR01AI154470 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI RANDOLPH, ADRIENNE G, THOMAS, PAUL G. · 2020 to 2024
$4.7M
Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5M
Investigating the cellular responses to influenza virus infection and the origins of first exposure immune imprintingF32AI157296 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI METTELMAN, ROBERT C · 2021 to 2023
$210k
NIAID NIH HHS 75N93021C00016NIAID NIH HHS F32 AI157296NIAID NIH HHS P01 AI165077NIAID NIH HHS R01 AI136514NIAID NIH HHS R01 AI154470NIAID NIH HHS U01 AI144616NICHD NIH HHS K12 HD000850NIGMS NIH HHS T32 GM136547
6 · The paper itself

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a severe, post-infectious sequela of SARS-CoV-2 infection

Indexed as

Antibodies, ViralAutoantibodiesCOVID-19Cross ReactionsEpitopesMolecular MimicrySARS-CoV-2Systemic Inflammatory Response SyndromeChildCoronavirus Nucleocapsid ProteinsHumansPhosphoproteinsSorting NexinsT-LymphocytesAntibodies, ViralAutoantibodiesCoronavirus Nucleocapsid ProteinsEpitopesnucleocapsid phosphoprotein, SARS-CoV-2PhosphoproteinsSNX8 protein, humanSorting Nexins

Identifiers

PMID39112696
PMCPMC11324515

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.