Evidence map›Paper›PMID 39112685›Full record

SynthesisNeurosurgical review2024

Endoscopic third ventriculostomy (ETV) for Chiari 1 malformation: a systematic review and meta-analysis.

Samantha Schimmel, Natasha Ram, Teagen Smith, Erik Hayman, Ivo Peto, Keaton Piper

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Samantha SchimmelMorsani College of Medicine, University of South Florida, Tampa, FL, USA.ORCID http://orcid.org/0000-0001-9860-8820
Natasha RamMorsani College of Medicine, University of South Florida, Tampa, FL, USA.
Teagen SmithMorsani College of Medicine, Research Methodology and Biostatistics Core, University of South Florida, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-5573-3178
Erik HaymanDepartment of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA.
Ivo PetoDepartment of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-6015-6862
Keaton PiperDepartment of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA. keatonpiper@usf.edu.ORCID http://orcid.org/0000-0002-5051-8866

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meta-analysis and systematic review. To understand the role of endoscopic third ventriculostomy (ETV) for the treatment of concurrent Chiari Malformation Type I (CMI) and hydrocephalus in adults. A literature search on PubMed and Medline with MeSH terms relating to ETV and CMI identified 155 articles between 1988 and 2024. After excluding pediatric cases and other CNS pathologies with associated CMI, 11 articles met inclusion criteria. The Newcastle-Ottawa Scale was identified to assess heterogeneity and risk of bias among the 11 studies analyzed in this systematic-review and meta-analyses compared pre- and post-operative outcomes to examine the use of ETV as a treatment modality for CMI with hydrocephalus. From the 11 included studies, 35 cases of concurrent CMI and hydrocephalus treated with ETV were identified. ETV provided a pooled rate of symptom resolution or improvement of 66%. Additionally, meta-analysis discovered the following pooled rates: a reduction of tonsillar descent in 94% of patients, decreased ventriculomegaly in 94%, and ETV patency in 99%. Syringomyelia, nausea, papilledema and cerebellar dysfunction did not have sufficient numbers for meaningful statistical analyses. However, in each of these categories, more than 85% of the symptoms or radiographic findings improved. This review summarizes the safety and efficacy of ETV for the concurrent management of acquired CMI with hydrocephalus. Specifically, ETV improves radiological outcomes of both ventriculomegaly and tonsillar descent as well as the most prevalent neurological symptom, headaches.

Indexed as

Arnold-Chiari MalformationHydrocephalusThird VentricleVentriculostomyHumansNeuroendoscopyTreatment OutcomeChiari malformation type 1Endoscopic third ventriculosmyHydrocephalusMeta-analysisTonsillar herniation

Identifiers

PMID39112685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.