Comparing CB1 receptor GIRK channel responses to receptor internalization using a kinetic imaging assay.

Haley K Andersen, Duncan G Vardakas, Julie A Lamothe, Tannis E A Perault, Kenneth B Walsh, Robert B Laprairie

Abstract readComparative Study

In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haley K AndersenCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.

Duncan G VardakasCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.

Julie A LamotheCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.

Tannis E A PeraultCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.

Kenneth B WalshPharmacology, Physiology, and Neuroscience, School of Medicine Columbia, University of South Carolina, Columbia, SC, USA.

Robert B LaprairieCollege of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada. robert.laprairie@usask.ca.

Funding

CIHR 201909PJT

6 · The paper itself

Abstract

The type 1 cannabinoid receptor (CB1R) mediates neurotransmitter release and synaptic plasticity in the central nervous system. Endogenous, plant-derived, synthetic cannabinoids bind to CB1R, initiating the inhibitory G-protein (G

Indexed as

BenzoxazinesG Protein-Coupled Inwardly-Rectifying Potassium ChannelsNaphthalenesReceptor, Cannabinoid, CB1AnimalsCannabinoidsCell LineCyclohexanolsHumansKineticsMiceMorpholinesSignal Transduction3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanoneBenzoxazinesCannabinoidsCyclohexanolsG Protein-Coupled Inwardly-Rectifying Potassium ChannelsMorpholinesNaphthalenesReceptor, Cannabinoid, CB1CannabinoidCannabinoid receptorG protein-coupled receptorReal-time assayReceptor signalingReceptor trafficking

Identifiers

PMID39112591

DOI10.1038/s41598-024-68451-2

PMCPMC11306342

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.