Evidence map›Paper›PMID 39112560›Full record

ArticleScientific reports2024

Genome-wide association study indicates novel associations of annexin A13 to secretory and GAS2L2 with mucous otitis media.

Argyro Bizaki-Vallaskangas, Joel Rämö, Eeva Sliz, Ilkka Kivekäs, Tytti Willberg, Elmo Saarentaus, Sanna Toppila-Salmi, Aarno Dietz, Teppo Haapaniemi, Vesa P Hytönen and 4 more

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Rare and low-frequency variants in families with otitis media.Journal of molecular medicine (Berlin, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Argyro Bizaki-VallaskangasDepartment of Otolaryngology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. argyro.bizaki-vallaskangas@tuni.fi.ORCID 0000-0001-9484-0913
Joel RämöInstitute for Molecular Medicine Finland and the Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Eeva SlizBiocenter Oulu and the Research Unit of Population Health, University of Oulu, Oulu, Finland.
Ilkka KivekäsDepartment of Otolaryngology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Tytti WillbergDepartment of Otolaryngology, Turku University Hospital, Turku, Finland.
Elmo SaarentausInstitute for Molecular Medicine Finland and the Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Sanna Toppila-SalmiDepartment of Otolaryngology, University of Eastern Finland, Kuopio, Finland.
Aarno DietzDepartment of Otolaryngology, University of Eastern Finland, Kuopio, Finland.
Teppo HaapaniemiFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Vesa P HytönenFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Sari ToivolaFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Aarno PalotieInstitute for Molecular Medicine Finland and the Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Antti MäkitieDepartment of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Johannes KettunenBiocenter Oulu and the Research Unit of Population Health, University of Oulu, Oulu, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the genetics of chronic nonsuppurative otitis media (OM). We performed a genome-wide association study of 429,599 individuals included in the FinnGen study using three different case definitions: combined chronic nonsuppurative OM (7034 cases) (included serous and mucous chronic OM), mucous chronic OM (5953 cases), and secretory chronic OM (1689 cases). Individuals without otitis media were used as controls (417,745 controls). We used immunohistochemistry (IHC) of the murine middle ear to evaluate the expression of annexin A13. Four loci were significantly associated (p < 1.7 × 10

Indexed as

AnnexinsGenome-Wide Association StudyOtitis MediaAnimalsEar, MiddleEustachian TubeFemaleGenetic Predisposition to DiseaseHumansMaleMicePolymorphism, Single NucleotideAnnexinsAnnexinEustachian tubeFinngenGAS2L2Genome-wide associationOtitis media

Identifiers

PMID39112560
PMCPMC11306868

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.