ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2024
Assessing the use of the novel tool Claude 3 in comparison to ChatGPT 4.0 as an artificial intelligence tool in the diagnosis and therapy of primary head and neck cancer cases.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Leveraging artificial intelligence to support surgical oncology multidisciplinary team decision-making: a systematic review.Frontiers in artificial intelligence · 2026Pooled it
- Applications of large language models in tumor boards: a systematic review.Oncology reviews · 2026Pooled it
- Clinical decision support using large language models in otolaryngology: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- Turing problems in otolaryngology: a scoping review of the principal challenges of artificial ıntelligence and large language models.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Review
- Article
- Precision oncology meets Generative AI: assessing large language models in multidisciplinary GIST tumor boards.BMC cancer · 2026Article
- Challenges in AI Based Tumor Board Case Summarization and Recommendations.Research square · 2026Article
- Comparison of the diagnostic accuracy of dentists and ChatGPT in jawbone lesions.BMC oral health · 2026Article
- Author's response to letter to editor for "Assessing the use of the novel tool Claude 3 in comparison to ChatGPT 4.0 as an artificial intelligence tool in the diagnosis and therapy of primary head and neck cancer cases".European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Evaluation of Artificial Intelligence as a Decision-Support Tool in Urological Tumor Boards: A Study in Real Clinical Practice.Journal of clinical medicine · 2026Article
- When AI joins the table: evaluating large language model performance in soft tissue sarcoma tumor board decisions.Journal of cancer research and clinical oncology · 2026Article
- Impact of Large Language Model Assistance on Radiologists' Diagnostic Performance for Brain Tumors by Experience Level.Journal of clinical medicine · 2026Article
- Accuracy of large language models in head and neck cancers: a comparative analysis of ChatGPT and Gemini in TNM staging and clinical decision support.Frontiers in oncology · 2026Article
- Vision language models versus machine learning models performance on polyp detection and classification in colonoscopy images.Scientific reports · 2025Article
- Large language models as information providers for appropriate antimicrobial use: computational text analysis and expert-rated comparison of ChatGPT, Claude and Gemini.BMJ health & care informatics · 2025Article
- Confirmation of Large Language Models in Head and Neck Cancer Staging.Diagnostics (Basel, Switzerland) · 2025Article
- Applications of Natural Language Processing in Otolaryngology: A Scoping Review.The Laryngoscope · 2025Article
- ChatGPT versus DeepSeek in head and neck cancer staging and treatment planning: guideline-based study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Harnessing advanced large language models in otolaryngology board examinations: an investigation using python and application programming interfaces.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Artificial intelligence in otorhinolaryngology: current trends and application areas.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Review
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesHead and neck squamous cell carcinoma (HNSCC) is a complex malignancy that requires a multidisciplinary tumor board approach for individual treatment planning. In recent years, artificial intelligence tools have emerged to assist healthcare professionals in making informed treatment decisions. This study investigates the application of the newly published LLM Claude 3 Opus compared to the currently most advanced LLM ChatGPT 4.0 for the diagnosis and therapy planning of primary HNSCC. The results were compared to that of a conventional multidisciplinary tumor board; (2) Materials and Methods: We conducted a study in March 2024 on 50 consecutive primary head and neck cancer cases. The diagnostics and MDT recommendations were compared to the Claude 3 Opus and ChatGPT 4.0 recommendations for each patient and rated by two independent reviewers for the following parameters: clinical recommendation, explanation, and summarization in addition to the Artificial Intelligence Performance Instrument (AIPI); (3) Results: In this study, Claude 3 achieved better scores for the diagnostic workup of patients than ChatGPT 4.0 and provided treatment recommendations involving surgery, chemotherapy, and radiation therapy. In terms of clinical recommendations, explanation and summarization Claude 3 scored similar to ChatGPT 4.0, listing treatment recommendations which were congruent with the MDT, but failed to cite the source of the information; (4) Conclusion: This study is the first analysis of Claude 3 for primary head and neck cancer cases and demonstrates a superior performance in the diagnosis of HNSCC than ChatGPT 4.0 and similar results for therapy recommendations. This marks the advent of a newly launched advanced AI model that may be superior to ChatGPT 4.0 for the assessment of primary head and neck cancer cases and may assist in the clinical diagnostic and MDT setting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.